The immune response of hepatocellular carcinoma after locoregional and systemic therapies: The available combination option for immunotherapy
作者全名："Duan, Yuxin; Zhang, Hua; Tan, Tao; Ye, Wentao; Yin, Kunli; Yu, Yanxi; Kang, Meiqing; Yang, Jian; Liao, Rui"
作者地址："[Duan, Yuxin; Zhang, Hua; Ye, Wentao; Yin, Kunli; Yu, Yanxi; Kang, Meiqing; Yang, Jian; Liao, Rui] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing, Peoples R China; [Tan, Tao] Chongqing Hlth Stat Informat Ctr, Chongqing, Peoples R China; [Liao, Rui] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing 400016, Peoples R China"
通信作者："Liao, R (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing 400016, Peoples R China."
来源：BIOSCIENCE TRENDS
ESI学科分类：BIOLOGY & BIOCHEMISTRY
WOS号：WOS:001106536900001
JCR分区：Q1
影响因子：5.5
年份：2023
卷号：
期号：
开始页：
结束页：
文献类型：Review; Early Access
关键词：Hepatocellular carcinoma; locoregional treatment; systemic treatment; immune therapy; immune microenvironment
摘要："Hepatocellular carcinoma (HCC) is associated with a highly heterogeneous immune environment that produces an immune response to various locoregional treatments (LRTs), which in turn affects the effectiveness of immunotherapy. Although LRTs still dominate HCC therapies, 50-60% of patients will ultimately be treated with systemic therapies and might receive those treatments for the rest of their life. TACE, SIRT, and thermal ablation can dramatically increase the immunosuppressive state of HCC, a condition that can be addressed by combination with immunotherapy to restore the activity of lymphocytes and the secretion of cellular immune factors. Immune treatment with locoregional and systemic treatments has dramatically changed the management of HCC. In this review, we examine the research on the changes in the immune microenvironment after locoregional or systemic treatment. We also summarize the regulation of various immune cells and immune factors in the tumor microenvironment and discuss the different infiltration degrees of immune cells and factors on the prognosis of HCC to better compare the efficacy between different treatment methods from the perspective of the tumor microenvironment. This information can be used to help develop treatment options for the upcoming new era of HCC treatment in the future."
基金机构："Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0112]; Science and Health Joint Research Project of Chongqing Municipality [2020GDRC013]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0087]"
基金资助正文："Funding : This research was supported by the Natural Science Foundation of Chongqing (No. CSTB2022NSCQ-MSX0112) ; Science and Health Joint Research Project of Chongqing Municipality (2020GDRC013) ; Program for Youth Innovation in Future Medicine, Chongqing Medical University (W0087) ."
