Gasdermin D: A Potential New Auxiliary Pan-Biomarker for the Detection and Diagnosis of Diseases

作者全名："Wan, Ningyi; Shi, Jing; Xu, Jianguo; Huang, Juan; Gan, Delu; Tang, Min; Li, Xiaohan; Huang, Ying; Li, Pu"

作者地址："[Wan, Ningyi; Xu, Jianguo; Gan, Delu; Li, Xiaohan; Huang, Ying; Li, Pu] Chongqing Med Univ, Dept Clin Lab, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Shi, Jing] Chongqing Med Univ, Dept Clin Lab, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Huang, Juan] Chongqing Med Univ, Dept Informat Ctr, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Tang, Min] Chongqing Med Univ, Key Lab Med Diagnost Designated, Chinese Minist Educ, Chongqing 400016, Peoples R China"

通信作者："Li, P (通讯作者)，Chongqing Med Univ, Dept Clin Lab, Affiliated Hosp 2, Chongqing 400010, Peoples R China."

来源：BIOMOLECULES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001107985600001

JCR分区：Q2

影响因子：5.5

年份：2023

卷号：13

期号：11

开始页：　

结束页：　

文献类型：Review

关键词：pyroptosis; gasdermin D; biomarker; diagnostic

摘要："Pyroptosis is a form of programmed cell death mediated by gasdermins, particularly gasdermin D (GSDMD), which is widely expressed in tissues throughout the body. GSDMD belongs to the gasdermin family, which is expressed in a variety of cell types including epithelial cells and immune cells. It is involved in the regulation of anti-inflammatory responses, leading to its differential expression in a wide range of diseases. In this review, we provide an overview of the current understanding of the major activation mechanisms and effector pathways of GSDMD. Subsequently, we examine the importance and role of GSDMD in different diseases, highlighting its potential as a pan-biomarker. We specifically focus on the biological characteristics of GSDMD in several diseases and its promising role in diagnosis, early detection, and differential diagnosis. Furthermore, we discuss the application of GSDMD in predicting prognosis and monitoring treatment efficacy in cancer. This review proposes a new strategy to guide therapeutic decision-making and suggests potential directions for further research into GSDMD."

基金机构：Chongqing Municipal Health Commission

基金资助正文："We thank all the authors participated in this review. The authors would like to thank the reviewers for their constructive comments and suggestions, which helped improve this work."