Impact of early cognitive impairment on outcome trajectory in patients with intracerebral hemorrhage

作者全名："Li, Zuo-Qiao; Bu, Xiao-Qing; Cheng, Jing; Deng, Lan; Lv, Xin-Ni; Wang, Zi-Jie; Hu, Xiao; Yang, Tian-Nan; Yin, Hao; Liu, Xue-Yun; Zhao, Li-Bo; Xie, Peng; Li, Qi"

作者地址："[Li, Zuo-Qiao; Deng, Lan; Lv, Xin-Ni; Wang, Zi-Jie; Hu, Xiao; Yang, Tian-Nan; Yin, Hao; Xie, Peng; Li, Qi] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Bu, Xiao-Qing] Chongqing Med Univ, Sch Publ Hlth, Dept Epidemiol, Chongqing, Peoples R China; [Cheng, Jing] Chongqing Med Univ, Dept Neurol & Neurosurg, Affiliated Hosp 3, Chongqing, Peoples R China; [Liu, Xue-Yun; Li, Qi] Anhui Med Univ, Dept Neurol, Affiliated Hosp 2, Hefei, Anhui, Peoples R China; [Zhao, Li-Bo] Chongqing Med Univ, Dept Neurol, Yongchuan Hosp, Chongqing, Peoples R China; [Zhao, Li-Bo; Li, Qi] Chongqing Key Lab Cerebrovascular Dis Res, Chongqing, Peoples R China; [Xie, Peng] Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Chongqing, Peoples R China; [Li, Qi] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Li, Q (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001109786300001

JCR分区：Q1

影响因子：5.3

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

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摘要："Objective: To assess the prevalence and factors associated with early cognitive impairment in intracerebral hemorrhage (ICH) patients and to describe short-term recovery trajectories among ICH patients with early cognitive impairment. Methods: We prospectively enrolled ICH patients without baseline dementia in our institutions. Cognitive function was assessed using mini-mental state examination (MMSE), and functional outcome was evaluated at discharge, 3, and 6 months after symptoms onset using the modified Rankin Scale (mRS). We used multinomial logistic regression models to investigate potential risk factors and generalized linear models to analyze the functional outcome data. Results: Out of 181 patients with ICH, 167 were included in the final analysis. Early cognitive impairment occurred in 60.48% of patients with ICH. Age (odds ratio [OR] per 1-year increase, 1.037; 95% confidence interval [CI], 1.003-1.071; p = 0.034), National Institutes of Health Stroke Scale (NIHSS) score (OR per 1-point increase, 1.146; 95% CI, 1.065-1.233; p < 0.001) and lobar ICH location (OR, 4.774; 95% CI, 1.810-12.593; p = 0.002) were associated with early cognitive impairment in ICH patients. Patients with >= 10 years of education were less likely to experience early cognitive impairment (OR, 0.323; 95% CI, 0.133-0.783; p = 0.012). Participants with early cognitive impairment had a higher risk of poor outcome (OR, 4.315; 95% CI, 1.503-12.393; p = 0.005) than those without. Furthermore, there was a significantly faster functional recovery rate for those without early cognitive impairment compared with those with at 3 and 6 months (p < 0.05). Interpretation: Early cognitive impairment was prevalent and associated with poor outcomes in ICH patients, which decelerated short-term functional recovery."

基金机构：Chongqing Innovation Support Program for Returned Overseas Chinese Scholars; National Natural Science Foundation of China [82071337]; Chongqing Science Fund for Distinguished Young Scholars [cstc2021jcyj-jqX0029]; [cx2020002]

基金资助正文："This study was supported by the National Natural Science Foundation of China (Grant No. 82071337), the Chongqing Science Fund for Distinguished Young Scholars (Grant No. cstc2021jcyj-jqX0029), the Chongqing Innovation Support Program for Returned Overseas Chinese Scholars (Grant No. cx2020002)."