Application of Ultrasound Shear Wave Elastography Combined With BRAFV600E Mutation for the Diagnosis of Papillary Thyroid Carcinoma

作者全名："Xu, Li; Haitao, Ran; Li, Zhou"

作者地址："[Xu, Li] Chongqing Med Univ, Bishan Hosp Chongqing, Bishan Hosp, Dept Ultrasound, Chongqing, Peoples R China; [Haitao, Ran; Li, Zhou] Chongqing Med Univ, Affiliated Hosp 2, Dept Ultrasound, Chongqing 400010, Peoples R China"

通信作者："Haitao, R; Li, Z (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Ultrasound, Chongqing 400010, Peoples R China."

来源：ULTRASOUND QUARTERLY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001110928800007

JCR分区：Q3

影响因子：1.3

年份：2023

卷号：39

期号：4

开始页：199

结束页：205

文献类型：Article

关键词：shear wave elasticity; BRAFV600E; papillary thyroid carcinoma; central cervical lymph node metastasis

摘要："This prospective study aimed to investigate the combination of shear wave elastography (SWE) and BRAFV600E mutation testing for the diagnosis of papillary thyroid carcinoma (PTC). One hundred thyroid nodules with an American College of Radiology thyroid imaging reporting and data system classification of 4 or 5 were subjected to SWE measurement, BRAFV600E genotyping, fine-needle aspiration, and surgery. Nonparametric statistical tests were used to compare the differences in the elastic parameters and BRAF genotypes between benign and malignant thyroid nodules of PTC, and receiver operating characteristic curve analysis was conducted to compare the diagnostic efficacy. In addition, the correlations between elastic parameters and BRAFV600E mutation in PTC were analyzed using binary logistic regression. The SWE, BRAFV600E, and their combination exhibited sensitivities of 72.9%, 81.3%, and 85.4%, respectively, and specificities of 66.7%, 90.3%, and 86.5%, respectively, in the diagnosis of PTC (P < 0.05). The SWE, BRAFV600E, and their combination exhibited sensitivities of 50.0%, 24.1% and 56.3%, respectively, and specificities of 89.7%, 87.5% and 82.8%, respectively, in the diagnosis of central cervical lymph node metastasis (P < 0.05). The combined use of SWE and BRAFV600E detection had the largest area under the curve, indicating that this combination is more effective in diagnosing PTC and lymph node metastasis in the central region than either method alone. Furthermore, Emax was positively associated with the BRAFV600E genotype. In conclusion, the combination of SWE and BRAFV600E genotype detection can improve the diagnostic efficacy for PTC. Emax can predict the BRAFV600E mutation status."

基金机构：Research Project of Bishan Hospital of Chongqing Medical University; [BYKY2023004]

基金资助正文："This was funded by the Research Project of Bishan Hospital of Chongqing Medical University. The project is titled ""Prediction of Central Lymph Node Metastasis in Papillary Thyroid Carcinoma Based on 'Stiff Rim Sign' of Shear Wave Elastography,"" with reference number BYKY2023004."