"Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions"

作者全名："Hu, Xulin; Wu, Haoming; Yong, Xin; Wang, Yao; Yang, Shuhao; Fan, Diyi; Xiao, Yibo; Che, Lanyu; Shi, Kun; Li, Kainan; Xiong, Chengdong; Zhu, Huili; Qian, Zhiyong"

作者地址："[Hu, Xulin; Wu, Haoming; Wang, Yao; Fan, Diyi; Xiao, Yibo; Che, Lanyu; Li, Kainan] Chengdu Univ, Clin Med Coll, Chengdu, Sichuan, Peoples R China; [Hu, Xulin; Shi, Kun; Qian, Zhiyong] Sichuan Univ, West China Hosp, Canc Ctr, Dept Biotherapy, Chengdu 610041, Sichuan, Peoples R China; [Hu, Xulin; Shi, Kun; Qian, Zhiyong] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China; [Yong, Xin] Sichuan Univ, West China Univ Hosp 2, Key Lab Birth Defects & Related Dis Women & Childr, Dept Paediat,State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China; [Yong, Xin] Sichuan Univ, Collaborat Innovat Ctr Biotherapy, Chengdu, Sichuan, Peoples R China; [Yang, Shuhao] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing, Peoples R China; [Xiong, Chengdong] Univ Chinese Acad Sci, Beijing, Peoples R China; [Zhu, Huili] Sichuan Univ, West China Univ Hosp 2, Key Lab Birth Defects Related Dis Women & Children, Dept Reprod Med,Minist Educ, Chengdu 610041, Sichuan, Peoples R China"

通信作者："Qian, ZY (通讯作者)，Sichuan Univ, West China Hosp, Canc Ctr, Dept Biotherapy, Chengdu 610041, Sichuan, Peoples R China.; Qian, ZY (通讯作者)，Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China.; Zhu, HL (通讯作者)，Sichuan Univ, West China Univ Hosp 2, Key Lab Birth Defects Related Dis Women & Children, Dept Reprod Med,Minist Educ, Chengdu 610041, Sichuan, Peoples R China."

来源：MEDCOMM

ESI学科分类：　

WOS号：WOS:001111634000001

JCR分区：Q1

影响因子：9.9

年份：2023

卷号：4

期号：6

开始页：　

结束页：　

文献类型：Review

关键词：biomaterial; endometrial repair; endometrium regeneration; menstrual cycle; regenerative medicine; tissue engineering scaffolds

摘要："The endometrium is a unique human tissue with an extraordinary ability to undergo a hormone-regulated cycle encompassing shedding, bleeding, scarless repair, and regeneration throughout the female reproductive cycle. The cyclical repair and regeneration of the endometrium manifest as changes in endometrial epithelialization, glandular regeneration, and vascularization. The mechanisms encompass inflammation, coagulation, and fibrinolytic system balance. However, specific conditions such as endometriosis or TCRA treatment can disrupt the process of cyclical endometrial repair and regeneration. There is uncertainty about traditional clinical treatments' efficacy and side effects, and finding new therapeutic interventions is essential. Researchers have made substantial progress in the perspective of regenerative medicine toward maintaining cyclical endometrial repair and regeneration in recent years. Such progress encompasses the integration of biomaterials, tissue-engineered scaffolds, stem cell therapies, and 3D printing. This review analyzes the mechanisms, diseases, and interventions associated with cyclical endometrial repair and regeneration. The review discusses the advantages and disadvantages of the regenerative interventions currently employed in clinical practice. Additionally, it highlights the significant advantages of regenerative medicine in this domain. Finally, we review stem cells and biologics among the available interventions in regenerative medicine, providing insights into future therapeutic strategies. This image summarizes diseases and therapeutic interventions for cyclic endometrial repair and regeneration. We summarize endometrial repair at different menstrual phases and the external factors contributing to endometrial repair imbalances. Current research advances in endometrial repair are outlined. Examples include hormone therapy, stem cell therapy, and so on.image"

基金机构：Natural Science Foundation of Sichuan Province; Chengdu Medical Research Project [2022004]; Natural Science Foundation of Clinical Medical College and Affiliated Hospital of Chengdu University; National Natural Science Foundation of China [81601258]; [23NSFSC5880]

基金资助正文："Figures 1, 2, and 3 were drawn with BioRender software, biorender.com. This work was supported by Natural Science Foundation of Sichuan Province-(23NSFSC5880), Chengdu Medical Research Project (2022004), Natural Science Foundation of Clinical Medical College and Affiliated Hospital of Chengdu University, and The National Natural Science Foundation of China (grant number 81601258). We thank Ms. Zhao and Mr. Zhang for their technical support."