EEG microstate analysis reveals large-scale brain network alterations in depressed adolescents with suicidal ideation

作者全名："He, Xiao-Qing; Hu, Jin-Hui; Peng, Xin-Yu; Zhao, Lin; Zhou, Dong-Dong; Ma, Ling-Li; Zhang, Zheng-Yong; Tao, Wan-Qing; Liu, Xin-Yi; Kuang, Li; Wang, Wo"

作者地址："[He, Xiao-Qing; Hu, Jin-Hui; Zhou, Dong-Dong; Zhang, Zheng-Yong; Tao, Wan-Qing; Liu, Xin-Yi; Wang, Wo] Chongqing Med Univ, Univ Town Hosp, Mental Hlth Ctr, Chongqing, Peoples R China; [Peng, Xin-Yu; Zhao, Lin; Ma, Ling-Li; Kuang, Li] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China; [Zhou, Dong-Dong; Wang, Wo] Chongqing Med Univ, Mental Hlth Ctr, Univ Town Hosp, Chongqing 401331, Peoples R China"

通信作者："Zhou, DD; Wang, W (通讯作者)，Chongqing Med Univ, Mental Hlth Ctr, Univ Town Hosp, Chongqing 401331, Peoples R China."

来源：JOURNAL OF AFFECTIVE DISORDERS

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001112067400001

JCR分区：Q1

影响因子：6.6

年份：2024

卷号：346

期号：　

开始页：57

结束页：63

文献类型：Article; Early Access

关键词：Major depressive disorder; Suicidal ideation; EEG microstates; Adolescents

摘要："Background: Accumulating evidence showed abnormalities in brain network connectivity in depressive individuals with suicidal ideation (SI). We aimed to investigate the large-scale brain network dynamics in adolescents with SI and major depressive disorder (MDD). Methods: We recruited 47 first-episode drug-naive adolescents with MDD and SI, 26 depressed adolescents without SI (noSI), and 26 age-matched healthy controls (HC). The Columbia Suicidal Ideation Severity Scale (C-SSRS) was utilized to assess suicide ideation. We acquired 64-channel resting-state EEG recordings from all subjects and used microstate analysis to investigate the large-scale brain network dynamics. Results: We observed a significant reduction in the occurrence and coverage of microstate B within the SI group when contrasted with the noSI group. Conversely, there was a significant increase in the occurrence and coverage of microstate A in the SI group as compared to the HC group. Additionally, we observed heightened transition probabilities from microstates D and C to microstate A in the SI group; meanwhile, transitions from microstate D to B were more prevalent in the noSI group. Furthermore, the noSI group exhibited a significant decline in the transition probabilities from microstate D to microstate C. Limitations: The cross-sectional nature limits the capacity to determine whether microstate dynamics have prognostic significance for SI. Conclusion: We provided evidence that depressed adolescents with SI have a distinct pattern in microstate dynamics compared to those without SI. These findings suggest that microstate dynamics might serve as a potential neurobiomarker for identifying SI in depressed adolescents."

基金机构：Chongqing Natural Science Foundation [CSTB2022NSCQ-MSX0138]; Chongqing Medical University [W0180]; Chongqing Science and Health Joint Project [2023QNXM050]

基金资助正文："This work was supported by the Chongqing Natural Science Foundation (CSTB2022NSCQ-MSX0138), the fund provided financial support for electroencephalogram technology learning among research members. This research was supported by the Program for ""Youth Innovation in Future Medicine"" (W0180), Chongqing Medical University, this fund covered support for the maintenance and update of EEG acquisition equipment. The Chongqing Science and Health Joint Project (2023QNXM050) also provided funding support for this study, the fund was used to purchase materials such as conductive pastes and electrode caps."