Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy

作者全名："Cao, Jiangjun; Zhang, Zhe; Zhou, Li; Luo, Maochao; Li, Lei; Li, Bowen; Nice, Edouard C.; He, Weifeng; Zheng, Shaojiang; Huang, Canhua"

作者地址："[Cao, Jiangjun; Luo, Maochao; Li, Bowen; Huang, Canhua] Sichuan Univ, West China Hosp, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China; [Cao, Jiangjun; Luo, Maochao; Li, Bowen; Huang, Canhua] Sichuan Univ, West China Hosp, Dept Biotherapy Canc Ctr, Chengdu 610041, Peoples R China; [Cao, Jiangjun; Luo, Maochao; Li, Bowen; Huang, Canhua] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China; [Zhang, Zhe] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Zhejiang Prov Key Lab Pancreat Dis, Hangzhou, Zhejiang, Peoples R China; [Zhou, Li] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Key Lab Mol Biol Infect Dis,Minist Educ,Dept Infec, Chongqing, Peoples R China; [Li, Lei] Hosp Chengdu Univ Tradit Chinese Med, Dept Anorectal Surg, Chengdu, Peoples R China; [Li, Lei] Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China; [Nice, Edouard C.] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic, Australia; [He, Weifeng] Third Mil Med Univ, Army Med Univ, State Key Lab Trauma Burns & Combined Injury, Southwest Hosp,Inst Burn Res, Chongqing 400030, Peoples R China; [Zheng, Shaojiang] Hainan Med Univ, Affiliated Hosp 1, Hainan Canc Med Ctr, Hainan Branch,Natl Clin Res Ctr Canc,Hainan Engn R, Haikou 570102, Peoples R China; [Zheng, Shaojiang] Hainan Med Univ, Hainan Women & Childrens Med Ctr, Key Lab Trop Cardiovasc Dis Res Hainan Prov, Key Lab Emergency & Trauma,Minist Educ, Haikou 571199, Peoples R China"

通信作者："Huang, CH (通讯作者)，Sichuan Univ, West China Hosp, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China.; Huang, CH (通讯作者)，Sichuan Univ, West China Hosp, Dept Biotherapy Canc Ctr, Chengdu 610041, Peoples R China.; Huang, CH (通讯作者)，Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China.; He, WF (通讯作者)，Third Mil Med Univ, Army Med Univ, State Key Lab Trauma Burns & Combined Injury, Southwest Hosp,Inst Burn Res, Chongqing 400030, Peoples R China.; Zheng, SJ (通讯作者)，Hainan Med Univ, Affiliated Hosp 1, Hainan Canc Med Ctr, Hainan Branch,Natl Clin Res Ctr Canc,Hainan Engn R, Haikou 570102, Peoples R China.; Zheng, SJ (通讯作者)，Hainan Med Univ, Hainan Women & Childrens Med Ctr, Key Lab Trop Cardiovasc Dis Res Hainan Prov, Key Lab Emergency & Trauma,Minist Educ, Haikou 571199, Peoples R China."

来源：MEDCOMM

ESI学科分类：　

WOS号：WOS:001112234200001

JCR分区：Q1

影响因子：9.9

年份：2023

卷号：4

期号：6

开始页：　

结束页：　

文献类型：Review

关键词：cancer therapy; drug resistance; embryonic development; tumor development and progression

摘要："Emerging evidence indicates that cancer cells can mimic characteristics of embryonic development, promoting their development and progression. Cancer cells share features with embryonic development, characterized by robust proliferation and differentiation regulated by signaling pathways such as Wnt, Notch, hedgehog, and Hippo signaling. In certain phase, these cells also mimic embryonic diapause and fertilized egg implantation to evade treatments or immune elimination and promote metastasis. Additionally, the upregulation of ATP-binding cassette (ABC) transporters, including multidrug resistance protein 1 (MDR1), multidrug resistance-associated protein 1 (MRP1), and breast cancer-resistant protein (BCRP), in drug-resistant cancer cells, analogous to their role in placental development, may facilitate chemotherapy efflux, further resulting in treatment resistance. In this review, we concentrate on the underlying mechanisms that contribute to tumor development and progression from the perspective of embryonic development, encompassing the dysregulation of developmental signaling pathways, the emergence of dormant cancer cells, immune microenvironment remodeling, and the hyperactivation of ABC transporters. Furthermore, we synthesize and emphasize the connections between cancer hallmarks and embryonic development, offering novel insights for the development of innovative cancer treatment strategies. Various regulatory mechanisms are involved in the development of a fertilized egg into an embryo to ensure that it proceeds normally. Meanwhile, cancer cells also exhibit several embryo-like characteristics that enhance multidrug resistance. (A) The level of corpus-secreted progesterone can be mediated by the inner or outer environment and lead to embryonic diapause. (a) Cancer cells are able to transition to a dormant state after treatment. (B) Wnt, Notch, Hedgehog, and Hippo signaling pathways contribute to development by driving the proliferation and differentiation of embryonic cells. (b) Cancer stem cells are considered drug-resistant cells associated with some embryonic developmental signaling pathways. (C) Preimplantation embryo was reported to drive the formation of immunosuppressive microenvironment to evade attack from maternal immune system. (c) The immune microenvironment components of cancer cells can confer resistance to immune checkpoint blockades (ICBs). (D) To export environmental toxins and provide a favorable condition for development, ABC transporters are usually overexpressed in the blood-embryo barrier. (d) ABC transporter overexpression in cancer cells results in the development of multidrug resistance.image"

基金机构：National Key Research and Development Program of China

基金资助正文："All images are created in whole or in part using BioRender (), and they have all obtained licenses."