"The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges"

作者全名："Ge, Feilin; Yang, Yan; Bai, Zhaofang; Si, Lanlan; Wang, Xuemei; Yu, Jia; Xiao, Xiaohe; Liu, Yan; Ren, Zhigang"

作者地址："[Ge, Feilin] Zhengzhou Univ, Affiliated Hosp 1, Dept Chinese Med, Zhengzhou 450052, Peoples R China; [Yang, Yan] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400010, Peoples R China; [Bai, Zhaofang; Si, Lanlan; Xiao, Xiaohe; Liu, Yan] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, Beijing 100039, Peoples R China; [Wang, Xuemei; Yu, Jia; Ren, Zhigang] Zhengzhou Univ, Affiliated Hosp 1, Dept Infect Dis, Zhengzhou 450052, Peoples R China"

通信作者："Xiao, XH; Liu, Y (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, Beijing 100039, Peoples R China.; Ren, ZG (通讯作者)，Zhengzhou Univ, Affiliated Hosp 1, Dept Infect Dis, Zhengzhou 450052, Peoples R China."

来源：CHINESE MEDICINE

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001112297000001

JCR分区：Q1

影响因子：4.9

年份：2023

卷号：18

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Traditional Chinese medicine; Hepatitis B virus; Nucleos(t)ide analogues; Functional cure; Antiviral mechanism

摘要："Chronic hepatitis B (CHB) remains a major world's most serious public health issues. Despite the remarkable effect of nucleos(t)ide analogues (NAs) in inhibiting hepatitis B virus (HBV) deoxyribonucleic acid (DNA) as the first-line drug, there are several limitations still, such as poor antigen inhibition, drug resistance, low-level viremia, restricting patients' functional cure. Due to the constraints of NAs, traditional medicines, such as traditional Chinese medicine (TCM), have become more prevalently used and researched in the clinical treatment of CHB as complementary alternative therapies. As a consequence, the review focuses on the background based on HBV's life cycle as well as the NAs' limitations, progress based on direct and indirect pathway of targeting HBV of TCM, and challenges of TCM. We found TCMs play an increasingly important role in anti-HBV. In a direct antiviral way, they regulate HBV infection, replication, assembly, and other aspects of the HBV life cycle. As for indirect way, TCMs can exert anti-HBV effects through targeting the host, including immune regulation, apoptosis, autophagy, oxidative stress, etc. Especially, TCMs have the advantages of strong antigenic inhibition compared to NAs. Specifically, we can combine the benefits of TCMs in strong HBV antigen inhibition with the benefits of NAs in targeted antiviral effects, in order to find a suitable combination of ""TCM + NAs"" to contribute to Chinese knowledge of the realisation of the ""global elimination of HBV by 2030"" goal of the World Health Organization."

基金机构：National Key Research and Development Program of China

基金资助正文：Not applicable.