Improving anti-Gram-positive-bacterial performance and osteogenesis for zinc alloy via mussel mimetic polydopamine with non-antibiotic lysozyme and parathyroid hormone

作者全名："Zhao, Deren; Chen, Tianhao; Chen, Jinqian; Huang, Banglun; Nie, Jihua; Liu, Hulin; Liu, Yangkai; Chen, Zilin; Zou, Feng; Lu, Qiqi; Tan, Xiaodong; Xiang, Yunjie; Li, Jing; Zhang, Yongping; Feng, Xue; Rao, Xi"

作者地址："[Zhao, Deren; Chen, Tianhao; Chen, Jinqian; Huang, Banglun; Nie, Jihua; Liu, Hulin; Liu, Yangkai; Chen, Zilin; Zou, Feng; Lu, Qiqi; Tan, Xiaodong; Xiang, Yunjie; Li, Jing; Zhang, Yongping; Rao, Xi] Southwest Univ, Sch Mat & Energy, Chongqing, Peoples R China; [Zhao, Deren; Chen, Tianhao; Chen, Jinqian; Huang, Banglun; Nie, Jihua; Liu, Hulin; Liu, Yangkai; Chen, Zilin; Zou, Feng; Lu, Qiqi; Tan, Xiaodong; Xiang, Yunjie; Li, Jing; Zhang, Yongping; Rao, Xi] Southwest Univ, Chongqing Key Lab Soft Matter Mat Chem & Funct Mfg, Chongqing, Peoples R China; [Feng, Xue] Chongqing Med Univ, Dept Clin Lab, Univ Town Hosp, Chongqing, Peoples R China"

通信作者："Rao, X (通讯作者)，Southwest Univ, Sch Mat & Energy, Chongqing, Peoples R China.; Rao, X (通讯作者)，Southwest Univ, Chongqing Key Lab Soft Matter Mat Chem & Funct Mfg, Chongqing, Peoples R China.; Feng, X (通讯作者)，Chongqing Med Univ, Dept Clin Lab, Univ Town Hosp, Chongqing, Peoples R China."

来源：BIOSURFACE AND BIOTRIBOLOGY

ESI学科分类：　

WOS号：WOS:001113289100001

JCR分区：　

影响因子：　

年份：2023

卷号：9

期号：4

开始页：199

结束页：209

文献类型：Article; Early Access

关键词：antibacterial; biocompatibility; non-antibiotic antimicrobial strategy

摘要："In this work, a novel coating with a non-antibiotic agent for inhibiting Gram-positive bacteria and promoting osteogenesis was prepared on zinc-aluminium alloy (ZA6-1) via mussel mimetic polydopamine (PDA) containing lysozyme (LYS) and parathyroid hormone (PTH). The results indicate that as-deposited coatings can efficiently decrease the degradation rate of ZA6-1 from 0.52 to 0.16 mm/year, and the addition of LYS weakens the coating resistance, while the addition of PTH enhances the coating resistance. In spite that no obvious inhibition of Escherichia coli is observed, the coated zinc alloys show good in vitro antibacterial performance against Staphylococcus aureus. Compared with ZA6-1 zinc alloys, the increase of antibacterial efficacy reaches 86.9%-90.1%. Furthermore, the lower hydrophilicity (26.4 degrees), higher osteoblast cell viability (>100%), good osteoblast cell morphology and better osteoblast cell differentiation (ALP = 107.7%) for PDA-LYS/PTH coated samples support that as-prepared coating is promising for modifying biodegradable zinc implants."

基金机构："National Natural Science Foundation of China; Natural Science Foundation of Chongqing, China [CSTB2023NSCQ-MSX0977]; Venture & Innovation Support Program for Chongqing Overseas Returnees [cx2021106]; [52271250]"

基金资助正文："The authors acknowledge support from the National Natural Science Foundation of China (grant 52271250), the Natural Science Foundation of Chongqing, China (grant CSTB2023NSCQ-MSX0977) and the Venture & Innovation Support Program for Chongqing Overseas Returnees (grant cx2021106)."