Prognostic value of pretreatment lymphocyte-to-monocyte ratio in patients with glioma: a meta-analysis

作者全名："Wang, Yan; Xu, Chu; Zhang, Zongxin"

作者地址："[Wang, Yan; Zhang, Zongxin] Huzhou Univ, Zhejiang Chinese Med Univ, Huzhou Cent Hosp, Clin Lab,Affiliated Cent Hosp,Sch Clin Med 5, Huzhou, Zhejiang, Peoples R China; [Xu, Chu] Chongqing Med Univ, Affiliated Hosp 3, Dept Neurosurg, Chongqing 401120, Peoples R China"

通信作者："Zhang, ZX (通讯作者)，Huzhou Univ, Zhejiang Chinese Med Univ, Huzhou Cent Hosp, Clin Lab,Affiliated Cent Hosp,Sch Clin Med 5, Huzhou, Zhejiang, Peoples R China."

来源：BMC MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001113420600001

JCR分区：Q1

影响因子：9.3

年份：2023

卷号：21

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Lymphocyte-to-monocyte ratio; Glioma; Meta-analysis; Evidence-based medicine; Biomarker

摘要："BackgroundMany studies have explored the prognostic role of the lymphocyte-to-monocyte ratio (LMR) in patients with glioma, but the results have been inconsistent. We therefore conducted the current meta-analysis to identify the accurate prognostic effect of LMR in glioma.MethodsThe electronic databases of PubMed, Web of Science, Embase, and Cochrane Library were thoroughly searched from inception to July 25, 2023. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to estimate the prognostic role of LMR for glioma.ResultsA total of 16 studies comprising 3,407 patients were included in this meta-analysis. A low LMR was significantly associated with worse overall survival (OS) (HR = 1.35, 95% CI = 1.13-1.61, p = 0.001) in glioma. However, there was no significant correlation between LMR and progression-free survival (PFS) (HR = 1.20, 95% CI = 0.75-1.91, p = 0.442) in glioma patients. Subgroup analysis indicated that a low LMR was significantly associated with inferior OS and PFS in glioma when using a cutoff value of <= 3.7 or when patients received mixed treatment.ConclusionsThis meta-analysis demonstrated that a low LMR was significantly associated with poor OS in glioma. There was no significant correlation between LMR and PFS in glioma patients. The LMR could be a promising and cost-effective prognostic biomarker in patients with glioma in clinical practice."

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