Perylene-Based Electrochemiluminescent Metal-Organic Frameworks for Detection of Zearalenone

作者全名："Lai, Dixuan; Mu, Zhaode; Zuo, Jianli; Zhou, Jiaxu; Zhang, Qifan; Chen, Keyu; Bai, Lijuan; Liang, Hongwen"

作者地址："[Lai, Dixuan; Mu, Zhaode; Zuo, Jianli; Zhou, Jiaxu; Zhang, Qifan; Chen, Keyu; Bai, Lijuan; Liang, Hongwen] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China"

通信作者："Bai, LJ; Liang, HW (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China."

来源：ACS APPLIED NANO MATERIALS

ESI学科分类：　

WOS号：WOS:001121877200001

JCR分区：Q2

影响因子：5.9

年份：2023

卷号：6

期号：23

开始页：22416

结束页：22425

文献类型：Article

关键词："electrochemiluminescence; zearalenone; perylene-3,4,9,10-tetracarboxylicacid; immunosensor; aggregation-caused quenching"

摘要："Synthesis of efficient electrochemiluminescent (ECL) luminescent materials is one of the effective means to improve the sensitivity of sensors. In this study, an efficient ECL-emitting nanomaterial, lanthanide metal-organic framework (PTCA-La-MOF, PLM) decorated with polycyclic aromatic hydrocarbon (PAH) derivative perylene-3,4,9,10-tetracarboxylic acid (PTCA), was synthesized for the sensitive detection of zearalenone (ZEN). The synthesized PLM nanomaterials effectively incorporated nanoscale features, allowing for efficient mass loading of PTCA while addressing the drawbacks of poor stability and easy aggregation in water. Moreover, the PLM exhibited a 2.4-fold increase in the ECL efficiency compared to PTCA aggregates due to the increase in ligand molecular spacing in PLM mitigated the aggregation-caused quenching (ACQ) effect of PTCA. Furthermore, the substrate material polyethylenimine (PEI)-functionalized NG nanocomposite doped with NiZn MOF (NG-PEI-NiZn MOF) could be used as an excellent sensing platform due to the reason that NG-PEI-NiZn MOF exhibited large specific surface area and excellent metallic conductivity. We demonstrated that ECL immunosensors using PLM as the signal amplifier and NG-PEI-NiZn MOF as the sensing matrix showed a significantly enhanced ECL signal with excellent selectivity for ZEN. We envision that the signal amplification strategy not only provided an effective approach for the detection of ZEN in food and cereals but also provided a convenient way to overcome the ACQ effect of PAHs and provide the ECL efficiency."

基金机构："Chongqing Medical University [82072378, 22007024, 81601856]; National Natural Science Foundation of China [CQYC202005015, cstc2021ycjh-bgzxm0328]; Chongqing Talents: Exceptional Young Talents Project, China [YS2019020]; Ba Yu Scholar Program, China [CSTB2022NSCQ-BHX0006, CSTB2023NSCQ-MSX0314]; Natural Science Foundation of Chongqing, China [2021XM2045]; Special Funding for Postdoctoral Research Project of Chongqing, China; Funds for High Level Young Science and Technology Talent Cultivation Plan in Chongqing Medical University, China [W0067]; Program for Youth Innovation in Future Medicine, Chongqing Medical University, China [YXY2019XSGG4, YXY2021BSH04]; Discipline Talent Training Program of College of Pharmacy in Chongqing Medical University, China"

基金资助正文："We gratefully acknowledge the financial support from the National Natural Science Foundation of China (82072378, 22007024, and 81601856), the Chongqing Talents: Exceptional Young Talents Project, China (CQYC202005015, cstc2021ycjh-bgzxm0328), the Ba Yu Scholar Program, China (YS2019020), the Natural Science Foundation of Chongqing, China (CSTB2022NSCQ-BHX0006 and CSTB2023NSCQ-MSX0314), the Special Funding for Postdoctoral Research Project of Chongqing, China (2021XM2045), the Funds for High Level Young Science and Technology Talent Cultivation Plan in Chongqing Medical University, China (2019), the Program for Youth Innovation in Future Medicine, Chongqing Medical University, China (W0067), and the Discipline Talent Training Program of College of Pharmacy in Chongqing Medical University, China (YXY2019XSGG4 and YXY2021BSH04)."