Nail psoriasis in China: A prospective multicentre study

作者全名:"Wang, Shiqi; Zhu, Jianjian; Wang, Ping; Dong, Jing; Li, Yanling; Shi, Dongmei; Wang, Huiping; Huang, Xi; Zhang, Xibao; Yu, Bo; Yang, Ziliang; Chen, Rixin; Wang, Xiaopeng; Li, Fuqiu; Bian, Kunpeng; Huo, Yuping; Yu, Nan; Li, Chen; Xia, Xiujuan; Lu, Jiejie; Li, Junjie; Lu, Yonghong; Xu, Yonghao; Ding, Yuan; Li, Yuzhen; Kang, Xiaojing; Li, Ruoyu"

作者地址:"[Wang, Shiqi; Li, Ruoyu] Peking Univ First Hosp, NMPA Key Lab Qual Control & Evaluat Cosmet, Beijing Key Lab Mol Diag Dermatoses, Natl Clin Res Ctr Skin & Immune Dis,Dept Dermatol, Beijing, Peoples R China; [Wang, Shiqi] Capital Med Univ, Beijing Chaoyang Hosp, Dept Dermatol, Beijing, Peoples R China; [Zhu, Jianjian] Cent South Univ, Peoples Hosp Changde 1, Changde Hosp, Xiangya Med Coll, Changde, Hunan, Peoples R China; [Wang, Ping] First Affiliated Hosp Chongqing Med Univ, Dept Orthoped, Chongqing, Peoples R China; [Dong, Jing] Wuhan No 1 Hosp, Dept Dermatol, Wuhan, Peoples R China; [Li, Yanling] Second Hosp Hebei Med Univ, Dept Oncol, Shijiazhuang, Peoples R China; [Shi, Dongmei] Jining No 1 Peoples Hosp, Dept Dermatol, Jining, Peoples R China; [Wang, Huiping] Tianjin Med Univ, Gen Hosp, Dept Dermatol, Tianjin, Peoples R China; [Huang, Xi] Guilin Med Coll, Affiliated Hosp, Dept Obstet & Gynecol, Guilin, Peoples R China; [Zhang, Xibao] Guangzhou Inst Dermatol, Dept Dermatol, Guangzhou, Peoples R China; [Yu, Bo] Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen, Peoples R China; [Yang, Ziliang] First Affiliated Hosp Soochow Univ, Dept Hematol, Suzhou, Peoples R China; [Chen, Rixin] Nanyang First Peoples Hosp, Dept Proctol, Nanyang 473012, Peoples R China; [Wang, Xiaopeng] Second Affiliated Hosp Xian Jiaotong Univ, Dept Dermatol, Xian, Peoples R China; [Li, Fuqiu] Second Hosp Jilin Univ, Dept Dermatol, Changchun, Peoples R China; [Bian, Kunpeng] Nanyang Cent Hosp, Dept Dermatol, Nanyang, Peoples R China; [Huo, Yuping] Xiamen Chang Gung Hosp, Dept Dermatol, Xiamen 361028, Peoples R China; [Yu, Nan] NingXia Med Univ, Gen Hosp, Dept Dermatol, Yinchuan, Peoples R China; [Li, Chen] Zhongshan City Peoples Hosp, Dept Dermatol, Zhongshan, Peoples R China; [Xia, Xiujuan] Yantai Yuhuangding Hosp, Dept Dermatol, Yantai, Peoples R China; [Lu, Jiejie] Fifth Peoples Hosp Hainan Prov, Dept Dermatol, Haikou, Hainan, Peoples R China; [Li, Junjie] Dongguan Peoples Hosp, Dept Otorhinolaryngol, Dongguan, Peoples R China; [Lu, Yonghong] Chengdu Second Peoples Hosp, Dept Dermatol, Chengdu, Peoples R China; [Xu, Yonghao] Shandong Univ, Qilu Hosp, Dept Dermatol, Jinan, Peoples R China; [Ding, Yuan; Kang, Xiaojing] Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Dermatol & Venereol, Xinjiang Clin Res Ctr Dermatol Dis, Key Lab Dermatol Res, Urumqi, Xinjiang, Peoples R China; [Li, Yuzhen] Harbin Med Univ, Affiliated Hosp 2, Dept Dermatol, Harbin, Peoples R China; Peking Univ First Hosp, Dept Neurol, 8 Xishiku St Xicheng Dist, Beijing 100034, Peoples R China"

通信作者:"Li, RY (通讯作者),Peking Univ First Hosp, NMPA Key Lab Qual Control & Evaluat Cosmet, Beijing Key Lab Mol Diag Dermatoses, Natl Clin Res Ctr Skin & Immune Dis,Dept Dermatol, Beijing, Peoples R China."











文献类型:Article; Early Access


摘要:"BackgroundData on nail psoriasis (PsO) in China are scarce.ObjectivesTo provide nail PsO-related data regarding epidemiologic characteristics, manifestations, fungal infections, arthritic complaints and treatments that may facilitate improved patient management globally.MethodsFrom August 2021 to August 2022, patients with nail PsO were enrolled in a prospective multicentre observational study at 25 hospitals in China. We collected and analysed data concerning nail PsO demography, clinical signs, fungal detection, arthritic symptoms and treatment.ResultsA total of 817 patients with nail PsO were involved, with a mean body mass index of 24.13 +/- 2.93. In addition, 71.41% of the patients were male. The Nail PsO Severity Index score was weakly positively correlated with body surface area. The percentage of nail involvement was 95.29% for fingernails and 57.18% for toenails, with pitting (67.11%) and subungual hyperkeratosis (60.40%) being the most prevalent manifestations, respectively. Toenails showed a significantly higher frequency of nailfold scales, subungual hyperkeratosis and nail plate crumbling and a lower frequency of splinter haemorrhages, pitting and erythema of the lunula. A total of 13.26% of the PsO patients had onychomycosis, and 77.08% were observed in the toenails. Articular symptoms were reported by 12.17% of the patients, with the peripheral type being predominant. Significant associations between articular symptoms and nailfold swelling, subungual hyperkeratosis, nailfold scales, onycholysis and longitudinal ridges were found. Only 2.30% (20 out of 871) of patients with nail PsO received treatment. The most frequently employed therapy for cutaneous PsO with nail involvement was biologic therapy (n = 366).ConclusionsPsO showed distinct manifestations in the toenails and fingernails. Additionally, toenail PsO combined with onychomycosis requires special attention. Articular symptoms in psoriatic patients are associated with specific nail changes. It is important to research and advocate for more potent treatments for nail PsO."

基金机构:National Key & D Program of China