"Inhibition of pathogenic microbes in oral infectious diseases by natural products: Sources, mechanisms, and challenges"

作者全名："Cao, Xin; Cheng, Xing-Wang; Liu, Yin-Ying; Dai, Hong-Wei; Gan, Ren-You"

作者地址："[Cao, Xin; Dai, Hong-Wei] Chongqing Med Univ, Coll Stomatol, 426 Songshibei Rd, Chongqing 401147, Peoples R China; [Cao, Xin; Dai, Hong-Wei] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China; [Cao, Xin; Dai, Hong-Wei] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China; [Cheng, Xing-Wang] Chongqing Med Univ, Ctr Joint Surg, Dept Orthoped Surg, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Liu, Yin-Ying; Gan, Ren-You] ASTAR, Singapore Inst Food & Biotechnol Innovat SIFBI, 31 Biopolis Way, Singapore 138669, Singapore; [Liu, Yin-Ying; Gan, Ren-You] Natl Univ Singapore, Fac Sci, Dept food Sci & technol, 2 Sci Dr 2, Singapore 117542, Singapore"

通信作者："Dai, HW (通讯作者)，Chongqing Med Univ, Coll Stomatol, 426 Songshibei Rd, Chongqing 401147, Peoples R China.; Gan, RY (通讯作者)，ASTAR, Singapore Inst Food & Biotechnol Innovat SIFBI, 31 Biopolis Way, Singapore 138669, Singapore."

来源：MICROBIOLOGICAL RESEARCH

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001126486500001

JCR分区：Q1

影响因子：6.7

年份：2024

卷号：279

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Oral infections; Natural products; Biological mechanisms; Therapy

摘要："The maintenance of oral health is of utmost importance for an individual's holistic well-being and standard of living. Within the oral cavity, symbiotic microorganisms actively safeguard themselves against potential foreign diseases by upholding a multifaceted equilibrium. Nevertheless, the occurrence of an imbalance can give rise to a range of oral infectious ailments, such as dental caries, periodontitis, and oral candidiasis. Presently, clinical interventions encompass the physical elimination of pathogens and the administration of antibiotics to regulate bacterial and fungal infections. Given the limitations of various antimicrobial drugs frequently employed in dental practice, the rising incidence of oral inflammation, and the escalating bacterial resistance to antibiotics, it is imperative to explore alternative remedies that are dependable, efficacious, and affordable for the prevention and management of oral infectious ailments. There is an increasing interest in the creation of novel antimicrobial agents derived from natural sources, which possess attributes such as safety, cost-effectiveness, and minimal adverse effects. This review provides a comprehensive overview of the impact of natural products on the development and progression of oral infectious diseases. Specifically, these products exert their influences by mitigating dental biofilm formation, impeding the proliferation of oral pathogens, and hindering bacterial adhesion to tooth surfaces. The review also encompasses an examination of the various classes of natural products, their antimicrobial mechanisms, and their potential therapeutic applications and limitations in the context of oral infections. The insights garnered from this review can support the promising application of natural products as viable therapeutic options for managing oral infectious diseases."

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