Nanomaterials for visualized tumor surgical navigation and postoperative recurrence inhibition

作者全名："Liang, Fuming; You, Qing; Ye, Hongjiang; Fu, Wenqiao; Ma, Xiaopeng; Tan, Jiahe; Ma, Yinrui; Wang, Chen; Yang, Yanlian; He, Zhaohui; Zhu, Ling"

作者地址："[Liang, Fuming; You, Qing; Wang, Chen; Yang, Yanlian; Zhu, Ling] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechnol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; [Liang, Fuming; Ye, Hongjiang; Fu, Wenqiao; Tan, Jiahe; Ma, Yinrui; He, Zhaohui] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing 400016, Peoples R China; [Ma, Xiaopeng] Univ Sci & Technol China, Affiliated Hosp 1, Anhui Prov Hosp, Hefei 230000, Peoples R China"

通信作者："Yang, YL; Zhu, L (通讯作者)，Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechnol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.; He, ZH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing 400016, Peoples R China."

来源：NANO RESEARCH

ESI学科分类：PHYSICS

WOS号：WOS:001127003900003

JCR分区：Q1

影响因子：9.9

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：nanomaterials; surgical navigation; tumor resection; tumor recurrence inhibition

摘要："Preoperative localization of the tumor sites and intraoperative real-time monitoring are essential for precise surgery but are meanwhile challenging due to the lack of high-resolution, easy-to-operate, and fast visualization techniques. On the other hand, tumor recurrence and metastasis after surgery greatly reduce the survival rate of patients. Intervening tumor recurrence during surgery is a future direction of tumor treatment. Nanomaterials with external condition responsiveness (light, ultrasound, and magnetic field) can accurately assist intraoperative detection and surgical resection due to their functions such as tumor cell targeting, fluorescence imaging, and real time monitoring, providing a more accurate, shorter duration, and visualization method of surgical resection. Moreover, nanomaterials are versatile and can easily be tailored for application in different tumors. Locally filled or systemically circulating nanomaterials with slow drug release and residual tumor cell-targeting ability have promising applications in inhibiting tumor recurrence. Here, we review surgical navigation and postoperative recurrence interventional nanomaterials and their landscape in guiding tumor treatment. We summarize the classification and characteristics of these nanomaterials and discuss their application in the surgical navigation and recurrence inhibition of different tumors. We also provide an outlook on the challenges and future development of nanomaterials for visualized tumor surgical navigation and postoperative recurrence inhibition."

基金机构："National Natural Science Foundation of China [31971295, 12374406, 27121002]; Strategic Priority Research Program of Chinese Academy of Science [XDB36000000]; Natural Science Foundation Project of Chongqing Science and Technology Commission [CSTB2023NSCQ-MSX0112]"

基金资助正文："The authors are grateful to the National Natural Science Foundation of China (Nos. 31971295, 12374406, and 27121002), Strategic Priority Research Program of Chinese Academy of Science (No. XDB36000000), and Natural Science Foundation Project of Chongqing Science and Technology Commission (No. CSTB2023NSCQ-MSX0112)."