Mechanism and application of <i>Lactobacillus</i> in type 2 diabetes-associated periodontitis

作者全名："Chen, Sisi; Zhang, Yuhan"

作者地址："[Chen, Sisi; Zhang, Yuhan] Chongqing Three Gorges Med Coll, Chongqing, Peoples R China; [Chen, Sisi; Zhang, Yuhan] Chongqing Med Univ, Chongqing, Peoples R China"

通信作者："Zhang, YH (通讯作者)，Chongqing Three Gorges Med Coll, Chongqing, Peoples R China.; Zhang, YH (通讯作者)，Chongqing Med Univ, Chongqing, Peoples R China."

来源：FRONTIERS IN PUBLIC HEALTH

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:001127006200001

JCR分区：Q1

影响因子：5.2

年份：2023

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：periodontitis; type II diabetes; Lactobacillus; mechanism; application

摘要："Type 2 diabetes mellitus (T2DM) accelerates the progression of periodontitis through diverse pathways. Abnormal immune responses, excessive activation of inflammation, increased levels of advanced glycation end products, and oxidative stress have defined roles in the pathophysiological process of T2DM-associated periodontitis. Furthermore, in the periodontium of diabetic individuals, there are high levels of advanced glycation end-products and glucose. Meanwhile, progress in microbiomics has revealed that dysbacteriosis caused by T2DM also contributes to the progression of periodontitis. Lactobacillus, owing to its fine-tuning function in the local microbiota, has sparked tremendous interest in this field. Accumulating research on Lactobacillus has detailed its beneficial role in both diabetes and oral diseases. In this study, we summarize the newly discovered mechanisms underlying Lactobacillus-mediated improvement of T2DM-associated periodontitis and propose the application of Lactobacillus in the clinic."

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