The positive efficacy of dexmedetomidine on the clinical outcomes of patients undergoing renal transplantation: evidence from meta-analysis

作者全名："Guo, Shanshan; Jia, Degong; Liu, Xueqi; Gao, Li; Wang, Huaying; Chen, Chaoyi; Wu, Yonggui"

作者地址："[Guo, Shanshan; Liu, Xueqi; Gao, Li; Wang, Huaying; Chen, Chaoyi; Wu, Yonggui] Anhui Med Univ, Affiliated Hosp 1, Dept Nephropathy, Hefei 230022, Anhui, Peoples R China; [Jia, Degong] Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing, Peoples R China; [Wu, Yonggui] Anhui Med Univ, Ctr Sci Res, Hefei 230022, Anhui, Peoples R China"

通信作者："Wu, YG (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Dept Nephropathy, Hefei 230022, Anhui, Peoples R China.; Wu, YG (通讯作者)，Anhui Med Univ, Ctr Sci Res, Hefei 230022, Anhui, Peoples R China."

来源：AGING-US

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001127645500020

JCR分区：Q2

影响因子：5.2

年份：2023

卷号：15

期号：23

开始页：14192

结束页：14209

文献类型：Article

关键词：renal transplantation; end-stage renal disease; dexmedetomidine; delayed graft function; meta-analysis

摘要："Introduction: Whether dexmedetomidine (DEX), an anesthetic adjuvant, can improve renal transplant outcomes is not clear. Methods: We systematically identified clinical trials in which DEX was administered in renal transplantation (RT). On November 1, 2022, we searched The Cochrane Library, MEDLINE, EMBASE and https://www.clinicaltrials.gov/. The main outcomes were delayed graft function and acute rejection. Results: A total of seven studies were included in the meta-analysis. The results showed that compared with the control, DEX significantly reduced the occurrence of delayed graft function (RR 0.76; 95% CI 0.60-0.98), short-term serum creatinine [postoperative day (POD) 2: (MD -22.82; 95% CI -42.01 - -3.64)] and blood urea nitrogen [POD 2: (MD -2.90; 95% CI -5.10 - -0.70); POD 3: (MD 2.07; 95% CI -4.12 - -0.02)] levels, postoperative morphine consumption (MD -4.27; 95% CI -5.92 - -2.61) and the length of hospital stay (MD -0.85; 95% CI-1.47 - -0.23). However, DEX did not reduce the risk of postoperative acute rejection (RR 0.75; 95% CI 0.45-1.23). The results of the subgroup analysis showed that country type, donor type, and average age had a certain impact on the role of DEX. Conclusions: DEX may improve the short-term clinical outcome of RT and shorten the length of hospital stay of patients."

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