"Risk factors for anastomotic leak and postoperative morbidity after right hemicolectomy for colon cancer: results from a prospective, multi-centre, snapshot study in China"
作者全名："Gao, Jiale; Gu, Xiaodong; Pang, Minghui; Zhang, Hong; Lian, Yugui; Zhou, Lei; Feng, Bo; Wang, Guiying; Zhang, Zhicao; Huang, He; Xiao, Gang; Han, Fanghai; Li, Xinxiang; Zhou, Xiaojun; Wang, Quan; Liu, Qian; Deng, Haijun; Wang, Zhenjun; Song, Wu; Wei, Zhengqiang; Li, Yong; Dai, Yong; Lin, Moubin; Zheng, Jianyong; Tang, Bo; He, Xianli; Wang, Hui; Liu, Fanlong; Li, Yongxiang; Zhou, Dongbing; Zhang, Wei; Ding, Kefeng; Tong, Weidong; He, Guodong; Jing, Changqing; Wu, Bin; Wu, Tao; Dong, Ming; Li, Zhifei; Shen, Zhanlong; Wei, Hongbo; Bai, Lian; Hu, Zhiqian; Tu, Shiliang; Qiu, Jian; Sun, Xuejun; Li, Ang; Zhuang, Jing; Yan, Su; Bonjer, Hendrik; Tuynman, Jurriaan; Yao, Hongwei; Zhang, Zhongtao"
作者地址："[Gao, Jiale; Yao, Hongwei; Zhang, Zhongtao] Capital Med Univ, Beijing Friendship Hosp, Natl Clin Res Ctr Digest Dis, Dept Gen Surg, Beijing, Peoples R China; [Gu, Xiaodong] Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai, Peoples R China; Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Geriatr Surg, Chengdu, Sichuan, Peoples R China; [Pang, Minghui] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Gastrointestinal Surg, Chengdu, Peoples R China; [Zhang, Hong] China Med Univ, Shengjing Hosp, Gen Surg Dept 4, Dept Colorectal Oncol, Shenyang, Peoples R China; [Lian, Yugui] Zhengzhou Univ, Dept Colorectal Surg, Affiliated Hosp 1, Zhengzhou, Peoples R China; [Zhou, Lei] China Japan Friendship Hosp, Dept Gen Surg, Beijing, Peoples R China; [Feng, Bo] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Gen Surg, Shanghai, Peoples R China; [Wang, Guiying] Hebei Med Univ, Hosp 2, Dept Gen Surg, Shijiazhuang, Peoples R China; [Zhang, Zhicao] Army Med Univ, Xinqiao Hosp, Dept Gen Surg, Chongqing, Peoples R China; [Huang, He] Shanxi Med Univ, Dept Gastrointestinal Surg, Hosp 1, Taiyuan, Peoples R China; [Xiao, Gang] Beijing Hosp, Natl Ctr Gerontol, Dept Gastrointestinal Surg, Beijing, Peoples R China; [Han, Fanghai] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gastrointestinal Surg, Guangzhou, Peoples R China; [Li, Xinxiang] Fudan Univ, Shanghai Canc Ctr, Dept Colorectal Surg, Shanghai, Peoples R China; [Zhou, Xiaojun] Soochow Univ, Dept Gen Surg, Affiliated Hosp 1, Suzhou, Peoples R China; [Wang, Quan] First Hosp Jilin Univ, Gen Surg Ctr, Dept Gastr & Colorectal Surg, Changchun, Peoples R China; [Liu, Qian] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Dept Colorectal Surg,Canc Hosp, Beijing, Peoples R China; [Deng, Haijun] Southern Med Univ, Nanfang Hosp, Dept Gen Surg, Guangzhou, Peoples R China; [Wang, Zhenjun] Capital Med Univ, Beijing Chao Yang Hosp, Dept Gen Surg, Beijing, Peoples R China; [Song, Wu] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Guangzhou, Peoples R China; [Wei, Zhengqiang] Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Chongqing, Peoples R China; [Li, Yong] Guangdong Prov Hosp, Dept Gastrointestinal Surg, Guangzhou, Guangdong, Peoples R China; [Li, Yong] Guangdong Prov Peoples Hosp, Dept Gen Surg, Guangzhou, Guangdong, Peoples R China; [Dai, Yong] Shandong Univ, Dept Gen Surg, Qilu Hosp, Jinan, Peoples R China; [Lin, Moubin] Tongji Univ, Sch Med, Yangpu Hosp, Dept Gen Surg, Shanghai, Peoples R China; [Zheng, Jianyong] Air Force Mil Med Univ, Dept Radiat Oncol, Affiliated Hosp 1, Xian, Peoples R China; [Tang, Bo] Third Mil Med Univ, Southwest Hosp, Dept Gen Surg, Ctr Minimally Invas Gastrointestinal Surg, Chongqing, Peoples R China; [He, Xianli] Air Force Med Univ, Tangdu Hosp, Dept Gen Surg, Xian, Peoples R China; [Wang, Hui] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Colorectal Surg, Guangzhou, Peoples R China; [Liu, Fanlong] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Colorectal Surg, Hangzhou, Peoples R China; [Li, Yongxiang] Anhui Med Univ, Dept Gen Surg, Affiliated Hosp 1, Hefei, Anhui, Peoples R China; [Zhou, Dongbing] North Sichuan Med Coll, Affiliated Nanchong Cent Hosp, Dept Gastrointestinal Surg, Nanchong, Peoples R China; [Zhang, Wei] Navy Mil Med Univ, Changhai Hosp, Dept Colorectal Surg, Shanghai, Peoples R China; [Ding, Kefeng] Zhejiang Univ, Affiliated Hosp 2, Dept Colorectal Surg & Oncol, Sch Med, Hangzhou, Peoples R China; [Tong, Weidong] Army Med Univ, Daping Hosp, Dept Gen Surg, Chongqing, Peoples R China; [He, Guodong] Fudan Univ, Zhongshan Hosp, Dept Colorectal Surg, Shanghai, Peoples R China; [Jing, Changqing] Shandong First Med Univ, Shandong Prov Hosp, Dept Gastrointestinal Surg, Jinan, Peoples R China; [Wu, Bin] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Gen Surg, Beijing, Peoples R China; [Wu, Tao] Peking Univ First Hosp, Dept Gen Surg, Beijing, Peoples R China; [Dong, Ming] China Med Univ, First Hosp, Dept Gastrointestinal Surg, Shenyang, Peoples R China; [Li, Zhifei] Peking Univ Third Hosp, Dept Gen Surg, Beijing, Peoples R China; [Shen, Zhanlong] Peking Univ, Peoples Hosp, Dept Gastroenterol Surg, Beijing, Peoples R China; [Wei, Hongbo] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Gastrointestinal Surg, Guangzhou, Peoples R China; [Bai, Lian] Chongqing Med Univ, Yongchuan Hosp, Dept Gastrointestinal Surg, Chongqing, Peoples R China; [Hu, Zhiqian] Tongji Univ, Coll Med, Tongji Hosp, Dept Gastrointestinal Surg, Shanghai, Peoples R China; [Tu, Shiliang] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Dept Colorectal Surg,Gen Surg,Canc Ctr, Hangzhou, Peoples R China; [Qiu, Jian] Shaanxi Prov Peoples Hosp, Dept Gen Surg, Xian, Peoples R China; [Sun, Xuejun] Xi An Jiao Tong Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Xian, Peoples R China; [Li, Ang] Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, Beijing, Peoples R China; [Zhuang, Jing] Zhengzhou Univ, Henan Canc Hosp, Dept Gen Surg, Affiliated Canc Hosp, Zhengzhou, Peoples R China; [Yan, Su] Qinghai Univ, Dept Gastrointestinal Surg Surg Oncol, Affiliated Hosp, Xining 810001, Qinghai Provinc, Peoples R China; [Bonjer, Hendrik; Tuynman, Jurriaan] Vrije Univ Amsterdam Med Ctr, Dept Surg, Amsterdam, Netherlands"
通信作者："Yao, HW; Zhang, ZT (通讯作者)，Capital Med Univ, Beijing Friendship Hosp, Natl Clin Res Ctr Digest Dis, Dept Gen Surg, 95 Yongan Rd, Beijing 100050, Peoples R China."
来源：BRITISH JOURNAL OF SURGERY
ESI学科分类：CLINICAL MEDICINE
WOS号：WOS:001127897100001
JCR分区：Q1
影响因子：9.6
年份：2024
卷号：111
期号：1
开始页：
结束页：
文献类型：Article; Early Access
关键词：
摘要："Background: Right hemicolectomy is the standard treatment for right-sided colon cancer. There is variation in the technical aspects of performing right hemicolectomy as well as in short-term outcomes. It is therefore necessary to explore best clinical practice following right hemicolectomy in expert centres.Methods: This snapshot study of right hemicolectomy for colon cancer in China was a prospective, multicentre cohort study in which 52 tertiary hospitals participated. Eligible patients with stage I-III right-sided colon cancer who underwent elective right hemicolectomy were consecutively enrolled in all centres over 10 months. The primary endpoint was the incidence of postoperative 30-day anastomotic leak.Results: Of the 1854 patients, 89.9 per cent underwent laparoscopic surgery and 52.3 per cent underwent D3 lymph node dissection. The overall 30-day morbidity and mortality were 11.7 and 0.2 per cent, respectively. The 30-day anastomotic leak rate was 1.4 per cent. In multivariate analysis, ASA grade > II (P < 0.001), intraoperative blood loss > 50 ml (P = 0.044) and D3 lymph node dissection (P = 0.008) were identified as independent risk factors for postoperative morbidity. Extracorporeal side-to-side anastomosis (P = 0.031), intraoperative blood loss > 50 ml (P = 0.004) and neoadjuvant chemotherapy (P = 0.004) were identified as independent risk factors for anastomotic leak.Conclusion: In high-volume expert centres in China, laparoscopic resection with D3 lymph node dissection was performed in most patients with right-sided colon cancer, and overall postoperative morbidity and mortality was low. Further studies are needed to explore the optimal technique for right hemicolectomy in order to improve outcomes further."
基金机构："National Key Technologies RD Program [2015BAI13B09]; National Key Technologies R&D Program of China [2017YFC0110904]; Clinical Center for Colorectal Cancer, Capital Medical University [1192070313]"
基金资助正文："This work was supported by grants from the National Key Technologies R&D Program (No. 2015BAI13B09), National Key Technologies R&D Program of China (No. 2017YFC0110904), Clinical Center for Colorectal Cancer, Capital Medical University (No. 1192070313)."
