Identification and Analyses of Crucial Genes Associated with Pathogenesis of Major Depressive Disorder

作者全名："Li, Jiao; Ma, Qing; Ai, Ming"

作者地址："[Li, Jiao] Chongqing Med Univ, Dept Clin Med 1, Chongqing, Peoples R China; [Ma, Qing] Univ Buffalo, Dept Pharm Practice, Buffalo, NY 14260 USA; [Ai, Ming] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China"

通信作者："Ai, M (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China."

来源：PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001128781300003

JCR分区：Q4

影响因子：0.7

年份：2023

卷号：33

期号：4

开始页：264

结束页：271

文献类型：Article

关键词：　

摘要："Background: Major depressive disorder is a debilitating mental condition that causes severe disability leading to a high fatality rate. No valid blood-based biomarkers for major depressive disorder are currently available. The purpose of this research is to investigate gene biomarkers and pathways that may be linked to major depressive disorder pathogenesis. Methods: Two microarray databases were retrieved from Gene Expression Omnibus for screening of candidate differentially expressed genes. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed followed by protein-protein interaction network of differentially expressed genes. Results: About 1181 differentially expressed genes were identified from the microarray databases. Gene Ontology analyses indicated that these differentially expressed genes were significantly enriched in mRNA splicing via spliceosome, neutrophil degranulation, peptide antigen assembly with MHC class II protein complex, and immunoglobulin production-mediated immune response. The most enriched Kyoto Encyclopedia of Genes and Genomes pathway terms of the 10 significant were Hematopoietic cell lineage. About 20 genes were identified as hub genes after pathway analyses, mostly involved in colorectal cancer and the composition of ribosomes and protein processing, including KRAS, CD86, RPL9, RPL3, and RPL18. Conclusion: New candidate genes have been identified using bioinformatic approaches that suggest their involvement in the pathogenesis of major depressive disorder and serve as potential genetic diagnostic markers as well as new therapeutic targets."

基金机构：Chongqing Medical Scientific Research Project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [2022MSXM058]; Chongqing Technology Innovation and Application Development Special Project [csct2020jscx-dxwtB0060-02]; Canadian Institutes of Health Research; Alberta Innovates Graduate Student Scholarship (AI-GSS)

基金资助正文：This research was supported by Chongqing Medical Scientific Research Project (Joint project of Chongqing Health Commission and Science and Technology Bureau) (2022MSXM058) . Chongqing Technology Innovation and Application Development Special Project (csct2020jscx-dxwtB0060-02).This work was supported by funding from the Canadian Institutes of Health Research (CG Scholarship to JJ) and the Alberta Innovates Graduate Student Scholarship (AI-GSS).