LncRNAs in non-small cell lung cancer: novel diagnostic and prognostic biomarkers

作者全名："Fu, Jiang; Yu, Li; Yan, Hang; Tang, Shengjie; Wang, Zixu; Dai, Tingting; Chen, Haoyu; Zhang, Song; Hu, Haiyang; Liu, Tao; Tang, Shoujun; He, Rong; Zhou, Haining"

作者地址："[Fu, Jiang; Yu, Li; Yan, Hang; Tang, Shengjie; Wang, Zixu; Dai, Tingting; Chen, Haoyu; Zhang, Song; Hu, Haiyang; Liu, Tao; Tang, Shoujun; Zhou, Haining] Chongqing Med Univ, Suining Cent Hosp, Affiliated Hosp, Dept Thorac Surg, Suining, Peoples R China; [Fu, Jiang; Wang, Zixu; Zhou, Haining] Chengdu Univ Tradit Chinese Med, Inst Surg, Grad Sch, Chengdu, Peoples R China; [Yu, Li] Chongqing Med Univ, Affiliated Hosp, Suining Cent Hosp, Dept Phys Examinat, Suining, Peoples R China; [Yan, Hang; Dai, Tingting; Hu, Haiyang; Zhou, Haining] Zunyi Med Univ, Inst Surg, Grad Sch, Zunyi, Peoples R China; [Chen, Haoyu; Zhang, Song; Zhou, Haining] North Sichuan Med Coll, Inst Surg, Grad Sch, Nanchong, Peoples R China; [He, Rong] Chongqing Med Univ, Suining Cent Hosp, Affiliated Hosp, Dept Resp & Crit Care Med, Suining, Peoples R China"

通信作者："Zhou, HN (通讯作者)，Chongqing Med Univ, Suining Cent Hosp, Affiliated Hosp, Dept Thorac Surg, Suining, Peoples R China.; Zhou, HN (通讯作者)，Chengdu Univ Tradit Chinese Med, Inst Surg, Grad Sch, Chengdu, Peoples R China.; Zhou, HN (通讯作者)，Zunyi Med Univ, Inst Surg, Grad Sch, Zunyi, Peoples R China.; Zhou, HN (通讯作者)，North Sichuan Med Coll, Inst Surg, Grad Sch, Nanchong, Peoples R China.; He, R (通讯作者)，Chongqing Med Univ, Suining Cent Hosp, Affiliated Hosp, Dept Resp & Crit Care Med, Suining, Peoples R China."

来源：FRONTIERS IN MOLECULAR BIOSCIENCES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001130302000001

JCR分区：Q2

影响因子：5

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：lung cancer; lncRNA; biomarker; diagnosis; prognosis; therapy

摘要："Non-small cell lung cancer (NSCLC) is one of the main causes of cancer-related death worldwide, with a serious impact on human health and life. The identification of NSCLC at an early stage is a formidable task that frequently culminates in a belated diagnosis. LncRNA is a kind of noncoding RNA with limited protein-coding capacity, and its expression is out of balance in many cancers, especially NSCLC. A large number of studies have reported that lncRNA acts a vital role in regulating angiogenesis, invasion, metastasis, and the proliferation and apoptosis of tumor cells, affecting the occurrence and development of NSCLC. Abundant evidence demonstrates that lncRNAs may serve as potential biomarkers for NSCLC diagnosis and prognosis. In this review, we summarize the latest progress in characterizing the functional mechanism of lncRNAs involved in the development of NSCLC and further discuss the role of lncRNAs in NSCLC therapy and chemotherapy resistance. We also discuss the advantages, limitations, and challenges of using lncRNAs as diagnostic or prognostic biomarkers in the management of NSCLC."

基金机构："Medical Science and Technology Project of Sichuan Provincial Health Commission [21PJ118, 2022yz102]"

基金资助正文："The authors declare financial support was received for the research, authorship, and/or publication of this article. Medical Science and Technology Project of Sichuan Provincial Health Commission: 21PJ118 and Research Project of Suining Central Hospital: 2022yz102."