"Association between oxidative stress exposure and colorectal cancer risk in 98,395 participants: results from a prospective study"

作者全名："Gu, Haitao; Li, Bo; Xiang, Ling; Xu, Zhiquan; Tang, Yunhao; Zhu, Zhiyong; Jiang, Yahui; Peng, Linglong; He, Hongmei; Wang, Yaxu"

作者地址："[Gu, Haitao; Li, Bo; Xiang, Ling; Xu, Zhiquan; Tang, Yunhao; Zhu, Zhiyong; Jiang, Yahui; Peng, Linglong; He, Hongmei; Wang, Yaxu] Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 2, Chongqing, Peoples R China; [Xiang, Ling] Chongqing Med Univ, Dept Clin Nutr, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："He, HM; Wang, YX (通讯作者)，Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：FRONTIERS IN NUTRITION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001132994900001

JCR分区：Q2

影响因子：5

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：oxidative stress exposure; colorectal cancer; epidemiology; sex-specific cohort studies; oxidative balance score

摘要："BackgroundThe intricate role of oxidative stress (OS) in colorectal cancer (CRC) initiation is underscored by an imbalance between pro-oxidants and antioxidants. Utilizing the Oxidative Balance Score (OBS) as a metric, this study aims to investigate the association between OS exposure and CRC risk, while also examining potential sex-specific differences in a large U.S. cohort.MethodsThe study included 98,395 adults from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. To construct the OBS, 14 dietary and lifestyle factors intricately associated with oxidative stress were quantified. A higher OBS value indicated a more favorable oxidative balance pattern or diminished OS exposure. Due to sex-specific differences in OBS, associations were evaluated separately for men and women based on Cox regression analysis. Subgroup analyses were conducted to elucidate potential modifiers.ResultsDuring 867,963.4 person-years of follow-up, 1,054 CRCs occurred. The mean (SD) age and OBS were 65.52 (5.73) years and 14.09 (3.95) points, respectively. In the fully adjusted Cox model, we observed an inverse association between OBS and CRC incidence in women (HRQ5vsQ1: 0.72; 95% CI: 0.52, 0.99; P for trend = 0.018) but not men. Subgroup analyses revealed the inverse association was more pronounced among women without versus with a family history of CRC (HRQ5 vsQ1: 0.66, 95% CI: 0.47-0.93; P for trend = 0.001; P for interaction = 0.001). The results remained robust after several sensitivity analyses.ConclusionHigher OBS was associated with lower CRC risk in women but not men; this inverse association was stronger among women without a family history of CRC. These findings suggest exposure to OS may confer sex-specific CRC risk effects, especially for women without a family history of CRC."

基金机构："Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission, China [cstc2021jcyj-msxmX0153, cstc2021jcyj-msxmX0112, CSTB2022NSCQ-MSX1005]; Kuanren Talents Project of the Second Affiliated Hospital of Chongqing Medical University in China [kryc-yq-2110]"

基金资助正文："The author(s) declare financial support was received for the research, authorship, and/or publication of the article. This work was supported by the Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission, China [cstc2021jcyj-msxmX0153 (LP)], [cstc2021jcyj-msxmX0112 (YW)], and [CSTB2022NSCQ-MSX1005 (HG)], and Kuanren Talents Project of the Second Affiliated Hospital of Chongqing Medical University in China [kryc-yq-2110 (HG)]."