Comparison of diffusion tensor imaging (DTI) tissue characterization parameters in white matter tracts of patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD)

作者全名："Chen, Xiaoya; Roberts, Neil; Zheng, Qiao; Peng, Yuling; Han, Yongliang; Luo, Qi; Feng, Jinzhou; Luo, Tianyou; Li, Yongmei"

作者地址："[Chen, Xiaoya; Zheng, Qiao; Peng, Yuling; Han, Yongliang; Luo, Qi; Feng, Jinzhou; Luo, Tianyou; Li, Yongmei] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400016, Peoples R China; [Roberts, Neil] Univ Edinburgh, Queens Med Res Inst, Edinburgh Imaging Facil QMRI, Edinburgh, Scotland"

通信作者："Luo, TY; Li, YM (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400016, Peoples R China."

来源：EUROPEAN RADIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001136211700008

JCR分区：Q1

影响因子：5.9

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Multiple sclerosis; Neuromyelitis optica spectrum disorder; Diffusion tensor imaging; White matter; Lesion

摘要："ObjectiveTo investigate the microstructural properties of T2 lesion and normal-appearing white matter (NAWM) in 20 white matter tracts between multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) and correlations between the tissue damage and clinical variables.MethodsThe white matter (WM) compartment of the brain was segmented for 56 healthy controls (HC), 48 patients with MS, and 38 patients with NMOSD, and for the patients further subdivided into T2 lesion and NAWM. Subsequently, the diffusion tensor imaging (DTI) tissue characterization parameters of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were compared for 20 principal white matter tracts. The correlation between tissue damage and clinical variables was also investigated.ResultsThe higher T2 lesion volumes of 14 fibers were shown in MS compared to NMOSD. MS showed more microstructure damage in 13 fibers of T2 lesion, but similar microstructure in seven fibers compared to NMOSD. MS and NMOSD had microstructure damage of NAWM in 20 fibers compared to WM in HC, with more damage in 20 fibers in MS compared to NMOSD. MS patients showed higher correlation between the microstructure of T2 lesion areas and NAWM. The T2 lesion microstructure damage was correlated with duration and impaired cognition in MS.ConclusionsPatients with MS and NMOSD show different patterns of microstructural damage in T2 lesion and NAWM areas. The prolonged disease course of MS may aggravate the microstructural damage, and the degree of microstructural damage is further related to cognitive impairment.Clinical relevance statementMicrostructure differences between T2 lesion areas and normal-appearing white matter help distinguish multiple sclerosis and neuromyelitis optica spectrum disorder. In multiple sclerosis, lesions rather than normal-appearing white matter should be a concern, because the degree of lesion severity correlated both with normal-appearing white matter damage and cognitive impairment.Key Points center dot Multiple sclerosis and neuromyelitis optica spectrum disorder have different damage patterns in T2 lesion and normal-appearing white matter areas.center dot The microstructure damage of normal-appearing white matter is correlated with the microstructure of T2 lesion in multiple sclerosis and neuromyelitis optica spectrum disorder.center dot The microstructure damage of T2 lesion in multiple sclerosis is correlated with duration and cognitive impairment.Key Points center dot Multiple sclerosis and neuromyelitis optica spectrum disorder have different damage patterns in T2 lesion and normal-appearing white matter areas.center dot The microstructure damage of normal-appearing white matter is correlated with the microstructure of T2 lesion in multiple sclerosis and neuromyelitis optica spectrum disorder.center dot The microstructure damage of T2 lesion in multiple sclerosis is correlated with duration and cognitive impairment.Key Points center dot Multiple sclerosis and neuromyelitis optica spectrum disorder have different damage patterns in T2 lesion and normal-appearing white matter areas.center dot The microstructure damage of normal-appearing white matter is correlated with the microstructure of T2 lesion in multiple sclerosis and neuromyelitis optica spectrum disorder.center dot The microstructure damage of T2 lesion in multiple sclerosis is correlated with duration and cognitive impairment."

基金机构：Key Project of Technological Innovation and Application Development of Chongqing Science and Technology Bureau

基金资助正文：All authors would like to thank all the subjects who participated in this study.