<i>Aspergillus fumigatus</i> escape mechanisms from its harsh survival environments

作者全名："Liu, Fangyan; Zeng, Meng; Zhou, Xue; Huang, Fujiao; Song, Zhangyong"

作者地址："[Liu, Fangyan; Zeng, Meng; Zhou, Xue; Huang, Fujiao; Song, Zhangyong] Southwest Med Univ, Sch Basic Med Sci, Luzhou 646000, Peoples R China; [Zeng, Meng] Chongqing Med Univ, Yongchuan Hosp, Dept Clin Lab, Chongqing 402160, Peoples R China; [Song, Zhangyong] Southwest Med Univ, Publ Ctr Expt Technol, Mol Biotechnol Platform, Luzhou 646000, Peoples R China"

通信作者："Song, ZY (通讯作者)，Southwest Med Univ, Sch Basic Med Sci, Luzhou 646000, Peoples R China.; Song, ZY (通讯作者)，Southwest Med Univ, Publ Ctr Expt Technol, Mol Biotechnol Platform, Luzhou 646000, Peoples R China."

来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001136257000002

JCR分区：Q2

影响因子：5

年份：2024

卷号：108

期号：1

开始页：18

结束页：21

文献类型：Review

关键词：Aspergillus fumigatus; Aspergillosis; Escape mechanisms; Immunity responses; Microecological agents; Drug resistance

摘要："Aspergillus fumigatus is a ubiquitous pathogenic mold and causes several diseases, including mycotoxicosis, allergic reactions, and systemic diseases (invasive aspergillosis), with high mortality rates. In its ecological niche, the fungus has evolved and mastered many reply strategies to resist and survive against negative threats, including harsh environmental stress and deficiency of essential nutrients from natural environments, immunity responses and drug treatments in host, and competition from symbiotic microorganisms. Hence, treating A. fumigatus infection is a growing challenge. In this review, we summarized A. fumigatus reply strategies and escape mechanisms and clarified the main competitive or symbiotic relationships between A. fumigatus, viruses, bacteria, or fungi in host microecology. Additionally, we discussed the contemporary drug repertoire used to treat A. fumigatus and the latest evidence of potential resistance mechanisms. This review provides valuable knowledge which will stimulate further investigations and clinical applications for treating and preventing A. fumigatus infections."

基金机构：Department of Science and Technology of Sichuan Province

基金资助正文：No Statement Available