SH2D4A inhibits esophageal squamous cell carcinoma progression through FAK/PI3K/AKT signaling pathway

作者全名："Shi, Haoming; Luo, Jun; Ye, Liu; Duan, Changzhu; Zhang, Min; Ran, Haoyu; Li, Changying; Wu, Qingchen; Shao, Yue"

作者地址："[Shi, Haoming; Luo, Jun; Zhang, Min; Ran, Haoyu; Li, Changying; Wu, Qingchen; Shao, Yue] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, Chongqing 400016, Peoples R China; [Ye, Liu] Chongqing Med Univ, Affiliated Hosp 1, Branch 1, Chongqing 400016, Peoples R China; [Duan, Changzhu] Chongqing Med Univ, Mol Med & Canc Res Ctr, Dept Cell Biol & Med Genet, Chongqing 400016, Peoples R China"

通信作者："Wu, QC; Shao, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, Chongqing 400016, Peoples R China.; Duan, CZ (通讯作者)，Chongqing Med Univ, Mol Med & Canc Res Ctr, Dept Cell Biol & Med Genet, Chongqing 400016, Peoples R China."

来源：CELLULAR SIGNALLING

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001137544500001

JCR分区：Q2

影响因子：4.8

年份：2024

卷号：114

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：ESCC; Proliferation; Migration; FAK /PI3K/AKT signaling pathway

摘要："Esophageal squamous cell carcinoma (ESCC), one of the most common malignant tumors, is now afflicting approximately 80% of patients diagnosed with esophageal cancers. The therapeutic effect and prognosis of ESCC remain inadequate due to the unusual early symptoms and rapid malignant progression. SH2 Domain containing 4 A (SH2D4A) is downregulated in malignancies and is closely associated with tumor progression. However, neither the biological functions nor the fundamental mechanisms of SH2D4A on ESCC are known. In this study, it was found that SH2D4A is downregulated in ESCC tissues and cell lines. Incorporating immunohistochemistry and clinicopathological findings, we determined that decreased SH2D4A expression was substantially associated with adverse clinical outcomes. Overexpression of SH2D4A inhibited cell proliferation and migration, whereas suppressing SH2D4A has the opposite effect. SH2D4A mechanistically inhibited cells from proliferating and migrating through the FAK/PI3K/AKT signaling pathway. Furthermore, the results of xenograft tumor growth confirmed the preceding findings. In conclusion, our findings reveal that SH2D4A is a gene which can serve as a cancer suppressor in ESCC and may inhibits the ESCC progression by interfering with the FAK/PI3K/AKT signaling pathway. SH2D4A could act as a target for diagnostic or therapeutic purpose in ESCC."

基金机构：Natural Science Foundation of China [82373003]; Innovation Program of The First Affiliated Hospital of Chongqing Medical University [CYYY-BSYJSCXXM-202228]; First Affiliated Hospital of Chongqing Medical University [PYJJ2022-05]

基金资助正文："This study was supported financially by the Natural Science Foundation of China (NO. 82373003) , Innovation Program of The First Affiliated Hospital of Chongqing Medical University (NO. CYYY-BSYJSCXXM-202228) and the First Affiliated Hospital of Chongqing Medical University (NO. PYJJ2022-05) ."