Association of Paternal Age Alone and Combined with Maternal Age with Perinatal Outcomes: A Prospective Multicenter Cohort Study in China

作者全名："Yin, Shaohua; Zhou, Yubo; Zhao, Cheng; Yang, Jing; Yuan, Pengbo; Zhao, Yangyu; Qi, Hongbo; Wei, Yuan"

作者地址："[Yin, Shaohua; Zhao, Cheng; Yang, Jing; Yuan, Pengbo; Zhao, Yangyu; Wei, Yuan] Peking Univ Third Hosp, Natl Clin Res Ctr Obstetr & Gynecol, Natl Ctr Healthcare Qual Management Obstet, Dept Obstet & Gynecol, 49 North Garden Rd, Beijing 100191, Peoples R China; [Yin, Shaohua; Zhao, Cheng; Yang, Jing; Yuan, Pengbo; Zhao, Yangyu; Wei, Yuan] Peking Univ Third Hosp, Natl Clin Res Ctr Obstetr & Gynecol, Beijing 100191, Peoples R China; [Zhou, Yubo] Peking Univ, Hlth Sci Ctr, Inst Reprod & Child Hlth, Natl Hlth Commiss Key Lab Reprod Hlth, Beijing 100191, Peoples R China; [Zhou, Yubo] Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China; [Qi, Hongbo] Chongqing Med Univ, Dept Obstet, Women & Childrens Hosp, 120 Longshan Rd, Chongqing 400021, Peoples R China"

通信作者："Wei, Y (通讯作者)，Peking Univ Third Hosp, Natl Clin Res Ctr Obstetr & Gynecol, Natl Ctr Healthcare Qual Management Obstet, Dept Obstet & Gynecol, 49 North Garden Rd, Beijing 100191, Peoples R China.; Wei, Y (通讯作者)，Peking Univ Third Hosp, Natl Clin Res Ctr Obstetr & Gynecol, Beijing 100191, Peoples R China.; Qi, HB (通讯作者)，Chongqing Med Univ, Dept Obstet, Women & Childrens Hosp, 120 Longshan Rd, Chongqing 400021, Peoples R China."

来源：JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH

ESI学科分类：　

WOS号：WOS:001137636000005

JCR分区：Q1

影响因子：7.3

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Paternal age; Maternal age; Perinatal outcomes; Joint association; Cohort study

摘要："Maternal and paternal age at birth is increasing globally. Maternal age may affect perinatal outcomes, but the effect of paternal age and its joint effect with maternal age are not well established. This prospective, multicenter, cohort analysis used data from the University Hospital Advanced Age Pregnant Cohort Study in China from 2016 to 2021, to investigate the separate association of paternal age and joint association of paternal and maternal age with adverse perinatal outcomes. Of 16,114 singleton deliveries, mean paternal and maternal age (+/- SD) was 38.0 +/- 5.3 years and 36.0 +/- 4.1 years. In unadjusted analyses, older paternal age was associated with increased risks of gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy, preeclampsia, placenta accreta spectrum disorders, placenta previa, cesarean delivery (CD), and postpartum hemorrhage, preterm birth (PTB), large-for-gestational-age, macrosomia, and congenital anomaly, except for small-for-gestational-age. In multivariable analyses, the associations turned to null for most outcomes, and attenuated but still significant for GDM, CD, PTB, and macrosomia. As compare to paternal age of < 30 years, the risks in older paternal age groups increased by 31-45% for GDM, 17-33% for CD, 32-36% for PTB, and 28-31% for macrosomia. The predicted probabilities of GDM, placenta previa, and CD increased rapidly with paternal age up to thresholds of 36.4-40.3 years, and then plateaued or decelerated. The risks of GDM, CD, and PTB were much greater for pregnancies with younger paternal and older maternal age, despite no statistical interaction between the associations related to paternal and maternal age. Our findings support the advocation that paternal age, besides maternal age, should be considered during preconception counseling.Trial Registration NCT03220750, Registered July 18, 2017-Retrospectively registered, https://classic.clinicaltrials.gov/ct2/show/NCT03220750."

基金机构：National Key Research and Development Program of China

基金资助正文："We are grateful to all health care workers who contributed to the data collection and the participants who supplied the data from the West China Second University Hospital, The Third Affiliated Hospital of Guangzhou Medical University, Shengjing Hospital, First Affiliated Hospital of Chongqing Medical University, Tongji Hospital, Obstetrics & Gynecology Hospital of Fudan University, Peking University Third Hospital, Peking University First Hospital."