Oral <sc>d</sc>-ribose causes depressive-like behavior by altering glycerophospholipid metabolism via the gut-brain axis

作者全名："Xu, Ke; Ren, Yi; Zhao, Shuang; Feng, Jinzhou; Wu, Qingyuan; Gong, Xue; Chen, Jianjun; Xie, Peng"

作者地址："[Xu, Ke; Ren, Yi; Feng, Jinzhou; Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China; [Xu, Ke; Ren, Yi; Wu, Qingyuan; Gong, Xue; Xie, Peng] Chongqing Med Univ, Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Natl Hlth Commiss, Chongqing 400016, Peoples R China; [Zhao, Shuang] Chongqing Med Univ, Inst Viral Hepatitis, Key Lab Mol Biol Infect Dis, Dept Infect Dis,Affiliated Hosp 2,Minist Educ, Chongqing 400010, Peoples R China; [Zhao, Shuang] Med Univ, Dept Histol & Embryol, Lab Stem Cell & Tissue Engn, Chongqing 400016, Peoples R China; [Wu, Qingyuan] Chongqing Univ, Three Gorges Hosp, Dept Neurol, Chongqing 404031, Peoples R China; [Chen, Jianjun] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China"

通信作者："Xie, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China.; Xie, P (通讯作者)，Chongqing Med Univ, Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Natl Hlth Commiss, Chongqing 400016, Peoples R China.; Chen, JJ (通讯作者)，Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China."

来源：COMMUNICATIONS BIOLOGY

ESI学科分类：　

WOS号：WOS:001139114900002

JCR分区：Q1

影响因子：5.9

年份：2024

卷号：7

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Our previous work has shown that d-ribose (RIB)-induced depressive-like behaviors in mice. However, the relationship between variations in RIB levels and depression as well as potential RIB participation in depressive disorder is yet unknown. Here, a reanalysis of metabonomics data from depressed patients and depression model rats is performed to clarify whether the increased RIB level is positively correlated with the severity of depression. Moreover, we characterize intestinal epithelial barrier damage, gut microbial composition and function, and microbiota-gut-brain metabolic signatures in RIB-fed mice using colonic histomorphology, 16 S rRNA gene sequencing, and untargeted metabolomics analysis. The results show that RIB caused intestinal epithelial barrier impairment and microbiota-gut-brain axis dysbiosis. These microbial and metabolic modules are consistently enriched in peripheral (fecal, colon wall, and serum) and central (hippocampus) glycerophospholipid metabolism. In addition, three differential genera (Lachnospiraceae_UCG-006, Turicibacter, and Akkermansia) and two types of glycerophospholipids (phosphatidylcholine and phosphatidylethanolamine) have greater contributions to the overall correlations between differential genera and glycerophospholipids. These findings suggest that the disturbances of gut microbiota by RIB may contribute to the onset of depressive-like behaviors via regulating glycerophospholipid metabolism, and providing new insight for understanding the function of microbiota-gut-brain axis in depression."

基金机构："National Key R&D Program of China (2017YFA0505700), Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019PT320002), National Natural Science Foundation of China (81820108015y. [2017YFA0505700]; National Key R&D Program of China [2019PT320002]; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [81820108015, 82301720]; National Natural Science Foundation of China [2023MD734128]; China Postdoctoral Science Foundation [CSTB2023NSCQ-BHX0214]; Chongqing Postdoctoral Science Foundation [CYYY-BSHPYXM-202310]; First Affiliated Hospital of Chongqing Medical University Postdoctoral Science Foundation"

基金资助正文："This study was supported by the National Key R&D Program of China (2017YFA0505700), the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019PT320002), the National Natural Science Foundation of China (81820108015, 82301720), the China Postdoctoral Science Foundation (2023MD734128), the Chongqing Postdoctoral Science Foundation (CSTB2023NSCQ-BHX0214), and the First Affiliated Hospital of Chongqing Medical University Postdoctoral Science Foundation (CYYY-BSHPYXM-202310)."