Signalling interaction between β-catenin and other signalling molecules during osteoarthritis development

作者全名："Feng, Jing; Zhang, Qing; Pu, Feifei; Zhu, Zhenglin; Lu, Ke; Lu, William W.; Tong, Liping; Yu, Huan; Chen, Di"

作者地址："[Feng, Jing; Pu, Feifei; Yu, Huan] Huazhong Univ Sci & Technol, Tradit Chinese & Western Med Hosp Wuhan, Tongji Med Coll, Dept Orthoped, Wuhan, Hubei, Peoples R China; [Feng, Jing; Pu, Feifei; Yu, Huan] Wuhan 1 Hosp, Dept Pediat, Wuhan, Hubei, Peoples R China; [Zhang, Qing] Wuhan Univ, Renmin Hosp, Dept Emergency, Wuhan, Hubei, Peoples R China; [Zhu, Zhenglin] Chongqing Med Univ, Dept Orthoped Surg, Affiliated Hosp 1, Chongqing, Peoples R China; [Lu, Ke; Lu, William W.; Chen, Di] Shenzhen Inst Adv Technol, Fac Pharmaceut Sci, Shenzhen, Peoples R China; [Lu, Ke; Tong, Liping; Chen, Di] Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Ctr Comp aided Drug Discovery, Shenzhen, Peoples R China; [Chen, Di] Shenzhen Inst Adv Technol, Fac Pharmaceut Sci, Shenzhen 518055, Peoples R China; [Yu, Huan] Huazhong Univ Sci & Technol, Tradit Chinese & Western Med Hosp Wuhan, Tongji Med Coll, Dept Orthoped, Wuhan 430022, Hubei, Peoples R China"

通信作者："Chen, D (通讯作者)，Shenzhen Inst Adv Technol, Fac Pharmaceut Sci, Shenzhen 518055, Peoples R China.; Yu, H (通讯作者)，Huazhong Univ Sci & Technol, Tradit Chinese & Western Med Hosp Wuhan, Tongji Med Coll, Dept Orthoped, Wuhan 430022, Hubei, Peoples R China."

来源：CELL PROLIFERATION

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001139385200001

JCR分区：Q2

影响因子：8.5

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：　

摘要："Osteoarthritis (OA) is the most prevalent disorder of synovial joint affecting multiple joints. In the past decade, we have witnessed conceptual switch of OA pathogenesis from a 'wear and tear' disease to a disease affecting entire joint. Extensive studies have been conducted to understand the underlying mechanisms of OA using genetic mouse models and ex vivo joint tissues derived from individuals with OA. These studies revealed that multiple signalling pathways are involved in OA development, including the canonical Wnt/beta-catenin signalling and its interaction with other signalling pathways, such as transforming growth factor beta (TGF-beta), bone morphogenic protein (BMP), Indian Hedgehog (Ihh), nuclear factor kappa B (NF-kappa B), fibroblast growth factor (FGF), and Notch. The identification of signalling interaction and underlying mechanisms are currently underway and the specific molecule(s) and key signalling pathway(s) playing a decisive role in OA development need to be evaluated. This review will focus on recent progresses in understanding of the critical role of Wnt/beta-catenin signalling in OA pathogenesis and interaction of beta-catenin with other pathways, such as TGF-beta, BMP, Notch, Ihh, NF-kappa B, and FGF. Understanding of these novel insights into the interaction of beta-catenin with other pathways and its integration into a complex gene regulatory network during OA development will help us identify the key signalling pathway of OA pathogenesis leading to the discovery of novel therapeutic strategies for OA intervention. The Wnt/beta-catenin signalling pathway plays critical roles in OA pathogenesis. Abnormal beta-catenin signalling in chondrocytes, synovial fibroblast and osteocytes leads to OA-like structural changes, such as progressive cartilage lesion, synovitis and sclerosis of subchondral bone and osteophyte formation.image"

基金机构：Wuhan Health Research Foundation

基金资助正文：No Statement Availabler No Statement Availabler No Statement Availabler No Statement Available