Palladium-catalysed fragmentary esterification-induced allylic alkylation of allyl carbonates and cyclic vinylogous anhydrides

作者全名："Wu, Shu-Yi; Li, Yang; Shen, Peng; Yang, Xin-Han; Ran, Guang-Yao"

作者地址："[Wu, Shu-Yi; Li, Yang; Shen, Peng; Yang, Xin-Han; Ran, Guang-Yao] Chongqing Med Univ, Coll Pharm, Dept Med Chem, Chongqing 400016, Peoples R China"

通信作者："Ran, GY (通讯作者)，Chongqing Med Univ, Coll Pharm, Dept Med Chem, Chongqing 400016, Peoples R China."

来源：CHEMICAL COMMUNICATIONS

ESI学科分类：CHEMISTRY

WOS号：WOS:001140047000001

JCR分区：Q2

影响因子：4.9

年份：2024

卷号：60

期号：11

开始页：1416

结束页：1419

文献类型：Article; Early Access

关键词：　

摘要："An unprecedented palladium-catalysed fragmentary esterification-induced allylic alkylation (FEAA) of cyclic vinylogous anhydrides (CVAs) and allyl carbonates has been disclosed. The protocol features broad sp3-rich scaffold tolerance, rendering highly functionalized 1,6 and 1,7-dicarbonyls in up to high yields and diastereoselectivities. Three-component FEAA is also well tolerant to generate 1,6-dicarbonyls through the addition of extra O/N-nucleophiles. Furthermore, cyclic allyl carbonate-involved FEAA provides an efficient approach for the synthesis of structurally complex medium-sized rings. A palladium-catalysed fragmental esterification-induced allylic alkylation of allylic carbonates with cyclic vinylogous anhydrides was disclosed, providing an efficient approach for the synthesis of 1,6/1,7-dicarbonyls and medium-sized rings."

基金机构：National Natural Science Foundation of China [22101038]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0310]

基金资助正文：This work was supported by the National Natural ScienceFoundation of China (22101038) and Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0310).