Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study

作者全名："Pan, Nanfang; Qin, Kun; Patino, Luis R.; Tallman, Maxwell J.; Lei, Du; Lu, Lu; Li, Wenbin; Blom, Thomas J.; Bruns, Kaitlyn M.; Welge, Jeffrey A.; Strawn, Jeffrey R.; Gong, Qiyong; Sweeney, John A.; Singh, Manpreet K.; Delbello, Melissa P."

作者地址："[Pan, Nanfang; Lu, Lu; Li, Wenbin; Gong, Qiyong; Sweeney, John A.] Sichuan Univ, West China Hosp, Chinese Acad Med Sci, Dept Radiol,Huaxi MR Res Ctr HMRRC,Res Unit Psycho, Chengdu, Peoples R China; [Pan, Nanfang; Qin, Kun] Hubei Univ Med, Taihe Hosp, Dept Radiol, Shiyan, Peoples R China; [Pan, Nanfang; Qin, Kun; Patino, Luis R.; Tallman, Maxwell J.; Lu, Lu; Blom, Thomas J.; Bruns, Kaitlyn M.; Welge, Jeffrey A.; Strawn, Jeffrey R.; Sweeney, John A.; Delbello, Melissa P.] Univ Cincinnati, Dept Psychiat, Cincinnati, OH USA; [Lei, Du] Chongqing Med Univ, Coll Med Informat, Chongqing, Peoples R China; [Gong, Qiyong] Sichuan Univ, West China Xiamen Hosp, Dept Radiol, Xiamen, OH, Peoples R China; [Singh, Manpreet K.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA USA; [Gong, Qiyong] Sichuan Univ, West China Xiamen Hosp, Dept Radiol, 699 Jinyuan Xi Rd, Xiamen 361021, Fujian, Peoples R China"

通信作者："Gong, QY (通讯作者)，Sichuan Univ, West China Xiamen Hosp, Dept Radiol, 699 Jinyuan Xi Rd, Xiamen 361021, Fujian, Peoples R China."

来源：JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001143108000001

JCR分区：Q1

影响因子：7.6

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Bipolar disorder; familial risk; fMRI; functional connectome; graph theory; psychoradiology

摘要："Background: Youth with a family history of bipolar disorder (BD) may be at increased risk for mood disorders and for developing side effects after antidepressant exposure. The neurobiological basis of these risks remains poorly understood. We aimed to identify biomarkers underlying risk by characterizing abnormalities in the brain connectome of symptomatic youth at familial risk for BD. Methods: Depressed and/or anxious youth (n = 119, age = 14.9 +/- 1.6 years) with a family history of BD but no prior antidepressant exposure and typically developing controls (n = 57, age = 14.8 +/- 1.7 years) received functional magnetic resonance imaging (fMRI) during an emotional continuous performance task. A generalized psychophysiological interaction (gPPI) analysis was performed to compare their brain connectome patterns, followed by machine learning of topological metrics. Results: High-risk youth showed weaker connectivity patterns that were mainly located in the default mode network (DMN) (network weight = 50.1%) relative to controls, and connectivity patterns derived from the visual network (VN) constituted the largest proportion of aberrant stronger pairs (network weight = 54.9%). Global local efficiency (E-local, p = .022) and clustering coefficient (C-p, p = .029) and nodal metrics of the right superior frontal gyrus (SFG) (E-local: p < .001; C-p: p = .001) in the high-risk group were significantly higher than those in healthy subjects, and similar patterns were also found in the left insula (degree: p = .004; betweenness: p = .005; age-by-group interaction, p = .038) and right hippocampus (degree: p = .003; betweenness: p = .003). The case-control classifier achieved a cross-validation accuracy of 78.4%. Conclusions: Our findings of abnormal connectome organization in the DMN and VN may advance mechanistic understanding of risk for BD. Neuroimaging biomarkers of increased network segregation in the SFG and altered topological centrality in the insula and hippocampus in broader limbic systems may be used to target interventions tailored to mitigate the underlying risk of brain abnormalities in these at-risk youth."

基金机构："National Institute of Mental Health [R01 MH097818, R01 MH105469]; NIMH [81621003, 81820108018, 82027808]; National Natural Science Foundation of China"

基金资助正文："This study was supported by an NIMH grant R01 MH097818 to M.D., R01 MH105469 to M.S., and the National Natural Science Foundation of China (Grants 81621003, 81820108018 and 82027808) to Q.G. and J.S."