Generation of a human iPSC line (CHCMUi002-A) from peripheral blood mononuclear cells from a chronic granulomatous disease patient

作者全名："Zeng, Anle; Ni, Ke; Fang, Shuyu; Yu, Lang; Gao, Yelei; Zhou, Lina; Zhao, Xiaodong"

作者地址："[Zeng, Anle; Fang, Shuyu; Yu, Lang; Gao, Yelei; Zhou, Lina; Zhao, Xiaodong] Childrens Hosp Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Child Infect & Immun, Minist Educ Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Zeng, Anle; Fang, Shuyu; Yu, Lang; Gao, Yelei; Zhou, Lina; Zhao, Xiaodong] Childrens Hosp Chongqing Med Univ, Div Rheumatol & Immunol, Chongqing, Peoples R China; [Ni, Ke] Aldit Therapeut, Hangzhou, Zhejiang, Peoples R China"

通信作者："Zhao, XD (通讯作者)，Childrens Hosp Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Child Infect & Immun, Minist Educ Key Lab Child Dev & Disorders, Chongqing, Peoples R China."

来源：STEM CELL RESEARCH

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001144067700001

JCR分区：Q4

影响因子：1.2

年份：2024

卷号：74

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Chronic granulomatous disease (CGD) is a rare X-linked recessive primary immunodeficiency disease (PID). Herein, a human induced pluripotent stem cell (iPSC) line was generated from the peripheral blood mononuclear cells (PBMCs) of a CGD patient with a mutation (c.785_786delTT) in the CYBB gene. These iPSCs showed the expression of pluripotency markers, the ability to differentiate into three germ layers. They offer a promising technique for studying the pathogenesis and conducting drug screening for CGD patients."

基金机构：Special Fund for the Central Govern- ment to Guide Local Science and Technology Development

基金资助正文：This work was supported by Special Fund for the Central Govern- ment to Guide Local Science and Technology Development.