Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study

作者全名："Wu, Kaiwen; Luo, Qiang; Liu, Ye; Li, Aoshuang; Xia, Demeng; Sun, Xiaobin"

作者地址："[Wu, Kaiwen; Li, Aoshuang; Sun, Xiaobin] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Affiliated Hosp, Dept Gastroenterol, Chengdu, Sichuan, Peoples R China; [Luo, Qiang] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Rheumatol & Immunol, Int Sci & Technol Cooperat base Child Dev & Crit D, Chongqing, Peoples R China; [Liu, Ye; Xia, Demeng] Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Dept Pharm, Shanghai, Peoples R China"

通信作者："Sun, XB (通讯作者)，Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Affiliated Hosp, Dept Gastroenterol, Chengdu, Sichuan, Peoples R China.; Xia, DM (通讯作者)，Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Dept Pharm, Shanghai, Peoples R China."

来源：JOURNAL OF TRANSLATIONAL MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001148364300001

JCR分区：Q1

影响因子：7.4

年份：2024

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Gut microbiota; Gastrointestinal disease; Mendelian randomization; SNPs

摘要："BackgroundRecent research increasingly highlights a strong correlation between gut microbiota and the risk of gastrointestinal diseases. However, whether this relationship is causal or merely coincidental remains uncertain. To address this, a Mendelian randomization (MR) analysis was undertaken to explore the connections between gut microbiota and prevalent gastrointestinal diseases.MethodsGenome-wide association study (GWAS) summary statistics for gut microbiota, encompassing a diverse range of 211 taxa (131 genera, 35 families, 20 orders, 16 classes, and 9 phyla), were sourced from the comprehensive MiBioGen study. Genetic associations with 22 gastrointestinal diseases were gathered from the UK Biobank, FinnGen study, and various extensive GWAS studies. MR analysis was meticulously conducted to assess the causal relationship between genetically predicted gut microbiota and these gastrointestinal diseases. To validate the reliability of our findings, sensitivity analyses and tests for heterogeneity were systematically performed.ResultsThe MR analysis yielded significant evidence for 251 causal relationships between genetically predicted gut microbiota and the risk of gastrointestinal diseases. This included 98 associations with upper gastrointestinal diseases, 81 with lower gastrointestinal diseases, 54 with hepatobiliary diseases, and 18 with pancreatic diseases. Notably, these associations were particularly evident in taxa belonging to the genera Ruminococcus and Eubacterium. Further sensitivity analyses reinforced the robustness of these results.ConclusionsThe findings of this study indicate a potential genetic predisposition linking gut microbiota to gastrointestinal diseases. These insights pave the way for designing future clinical trials focusing on microbiome-related interventions, including the use of microbiome-dependent metabolites, to potentially treat or manage gastrointestinal diseases and their associated risk factors."

基金机构：Nature Science Foundation of Hainan; MiBioGen consortium for releasing the gut microbiota GWAS summary statistics

基金资助正文：The authors express their gratitude to the participants and investigators of the UK Biobank and FinnGen study. The authors also appreciate the MiBioGen consortium for releasing the gut microbiota GWAS summary statistics.