Stroke and Risk Factors in Antiphospholipid Syndrome

作者全名："Fan, Yangyi; Xu, Yicheng; Zhang, Sifan; Song, Xiaodong; Liu, Zunjing; Tu, Wenjun; Li, Chun"

作者地址："[Fan, Yangyi; Song, Xiaodong; Liu, Zunjing] Peking Univ Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China; [Xu, Yicheng] Aerosp Ctr Hosp, Dept Neurol, Beijing 100049, Peoples R China; [Zhang, Sifan] Peking Univ Peoples Hosp, Beijing 100191, Peoples R China; [Song, Xiaodong] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400042, Peoples R China; [Tu, Wenjun] Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China; [Li, Chun] Peking Univ Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China"

通信作者："Tu, WJ (通讯作者)，Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China.; Li, C (通讯作者)，Peking Univ Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China."

来源：JOURNAL OF PERSONALIZED MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001151404500001

JCR分区：　

影响因子：　

年份：2024

卷号：14

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：stroke; antiphospholipid; risk factor; stroke recurrence

摘要："Stroke is considered one of the most common and life-threatening manifestations of antiphospholipid syndrome (APS), which leads to high mortality and permanent disability. This study investigated the prevalence and the potential risk factors of stroke in APS. We enrolled 361 APS patients retrospectively from 2009 to 2022 at Peking University People's Hospital. Stroke was found in 25.8% (93/361) of the participants. The multivariate logistic regression showed that hypertension, diabetes, livedo reticularis, and other central nervous system involvements were significant related factors for stroke. The use of hydroxychloroquine appeared to relate to a lower incidence of stroke. During a median follow-up of 3.0 years, 11.8% (11/93) of the individuals with a previous stroke developed stroke recurrence, and thrombocytopenia seemed to be a predictor of stroke recurrence."

基金机构：China International Medical Foundation

基金资助正文：We appreciate the study subjects and the assistance of the members involved in the survey and follow-up of this study. All individuals included in this section have consented to the acknowledgement.