"Comparison of NAFLD, MAFLD and MASLD characteristics and mortality outcomes in United States adults"

作者全名："Song, Rui; Li, Zhao; Zhang, Yingzhi; Tan, Jiahe; Chen, Zhiwei"

作者地址："[Song, Rui; Zhang, Yingzhi; Chen, Zhiwei] Chongqing Med Univ, Inst Viral Hepatitis, Dept Infect Dis, Key Lab Mol Biol Infect Dis,Affiliated Hosp 2,Mini, Chongqing, Peoples R China; [Li, Zhao] Seventh Peoples Hosp Chongqing, Dept Gastroenterol, Chongqing, Peoples R China; [Tan, Jiahe] Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Chongqing, Peoples R China; [Chen, Zhiwei] Chongqing Med Univ, Inst Viral Hepatitis, Dept Infect Dis, Key Lab Mol Biol Infect Dis,Affiliated Hosp 2,Mini, 74 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Chen, ZW (通讯作者)，Chongqing Med Univ, Inst Viral Hepatitis, Dept Infect Dis, Key Lab Mol Biol Infect Dis,Affiliated Hosp 2,Mini, 74 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：LIVER INTERNATIONAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001154749700001

JCR分区：Q1

影响因子：6.7

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：MAFLD; MASLD; mortality; NAFLD; NHANES III

摘要："Background & Aims: Following the classification of metabolic dysfunction-associated fatty liver disease (MAFLD), non-alcoholic fatty liver disease (NAFLD) has recently been redefined again as metabolic dysfunction-associated steatotic liver disease (MASLD). However, the distinctions in characteristics and mortality outcomes between NAFLD, MAFLD and MASLD remain unclear. Methods: We analysed data from 7519 participants in the third National Health and Nutrition Examination Surveys of United States (US) and their linked mortality until 2019. Survey weight-adjusted multivariable Cox proportional model was used to study the mortality over three terms. Results: The prevalence of NAFLD, MAFLD and MASLD was 18.5%, 19.3% and 20.8%, respectively. Most individuals with NAFLD (94.5%) or MAFLD (100%) can be classified as MASLD, while a relatively low percentage of those with MASLD were also diagnosed with either NAFLD (84.1%) or MAFLD (92.7%). During a median follow-up of 26.9 years, both MAFLD and MASLD were associated with increased risk of all-cause mortality (adjusted hazard ratio [aHR] 1.18, 95% CI 1.04-1.33 and 1.19, 1.06-1.34, respectively), this association was mainly observed in NAFLD-/MASLD+ subgroups. NAFLD was not associated with all-cause mortality. However, all three terms were associated with an increased risk of all-cause mortality in individuals with advanced fibrosis (aHR: 1.71-1.81). Subgroup analyses showed that higher risk of all-cause mortality for both MAFLD and MASLD were observed among older adults (>= 65 year), non-Hispanic whites and those without diabetes. Conclusions: Both MASLD and MALFD were linked to higher all-cause mortality risk, but MASLD identified a greater number of individuals compared to MAFLD."

基金机构：First Batch of Key Disciplines on Public Health in Chongqing

基金资助正文：the First Batch of Key Disciplines on Public Health in Chongqing