Stimuli-responsive peptide hydrogels for biomedical applications

作者全名："Zhou, Haoran; Zhu, Yanhua; Yang, Bingbing; Huo, Yehong; Yin, Yuanyuan; Jiang, Xuemei; Ji, Wei"

作者地址："[Zhou, Haoran; Zhu, Yanhua; Yang, Bingbing; Huo, Yehong; Jiang, Xuemei; Ji, Wei] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China; [Yin, Yuanyuan] Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Stomatol Hosp, Chongqing 401147, Peoples R China"

通信作者："Jiang, XM; Ji, W (通讯作者)，Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China."

来源：JOURNAL OF MATERIALS CHEMISTRY B

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001155377400001

JCR分区：Q2

影响因子：7

年份：2024

卷号：12

期号：7

开始页：1748

结束页：1774

文献类型：Review; Early Access

关键词：　

摘要："Stimuli-responsive hydrogels can respond to external stimuli with a change in the network structure and thus have potential application in drug release, intelligent sensing, and scaffold construction. Peptides possess robust supramolecular self-assembly ability, enabling spontaneous formation of nanostructures through supramolecular interactions and subsequently hydrogels. Therefore, peptide-based stimuli-responsive hydrogels have been widely explored as smart soft materials for biomedical applications in the last decade. Herein, we present a review article on design strategies and research progress of peptide hydrogels as stimuli-responsive materials in the field of biomedicine. The latest design and development of peptide hydrogels with responsive behaviors to stimuli are first presented. The following part provides a systematic overview of the functions and applications of stimuli-responsive peptide hydrogels in tissue engineering, drug delivery, wound healing, antimicrobial treatment, 3D cell culture, biosensors, etc. Finally, the remaining challenges and future prospects of stimuli-responsive peptide hydrogels are proposed. It is believed that this review will contribute to the rational design and development of stimuli-responsive peptide hydrogels toward biomedical applications. This review summarizes the design strategies and recent research progress of stimuli-responsive peptide hydrogels for biomedical applications."

基金机构：National Natural Science Foundation of China [52103148]; National Natural Science Foundation of China; Chongqing University

基金资助正文："This work was supported by the National Natural Science Foundation of China (No. 52103148), the Start-up Funding from Chongqing University. The authors thank Mr Jiawei Sun for helpful discussions."