Fabrication of docetaxel-loaded hyaluronic acid coated zeolitic imidazolate framework-8 as an effective treatment for leukaemia cancer cells and its apoptosis induction

作者全名："Wu, Shuyi; Li, Henghua; Su, Di; Lu, Na"

作者地址："[Wu, Shuyi; Li, Henghua] Chongqing Acad Chinese Mat Med, Inst Pharmacol & Toxicol, Chongqing, Peoples R China; [Su, Di; Lu, Na] Chongqing Med Univ, Basic Med Coll, Chongqing, Peoples R China; [Li, Henghua] Chongqing Acad Chinese Mat Med, Inst Pharmacol & Toxicol, Chongqing 400060, Peoples R China"

通信作者："Li, HH (通讯作者)，Chongqing Acad Chinese Mat Med, Inst Pharmacol & Toxicol, Chongqing 400060, Peoples R China."

来源：JOURNAL OF EXPERIMENTAL NANOSCIENCE

ESI学科分类：CHEMISTRY

WOS号：WOS:001156906000001

JCR分区：Q2

影响因子：2.8

年份：2024

卷号：19

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Apoptosis; docetaxel; drug delivery systems; hyaluronic acid; leukaemia cancer; zeolitic imidazolate framework-8

摘要："Drug delivery systems (DDSs) have been developed to carry an appropriate payload into the tumour's area, accomplishing the goals of minimising potential bodily harm and enhancing therapeutic efficacy. Here, we fabricated a one-pot method for encasing docetaxel (DTX) in zeolitic imidazolate framework-8 (ZIF-8) composites called DTX@ZIF-8. The DTX@ZIF-8/HA nanoplatform is then formed by coating the DTX@HA with a hyaluronic acid (HA). Notably, the loading rate increased to 43.0% at a DTX dose of 1 mg/mL. The findings confirmed that HA could prolong blood flow and improve the tumour-specific formation of DDS. It may also be an innovative 'switch' and tumour-targeted 'guider'. Hyaluronidase (HAase) in the tumour microenvironment (TME) may break down the HA shell, exposing the wrapped DTX@ZIF-8 and causing ZIF-8 to break down in the acidic tumour microenvironment, releasing the loaded DTX. The apoptosis mechanism was investigated using various biochemical staining and flow cytometric analysis. As a result, the DTX@ZIF-8/HA nanoplatforms were developed as an on-demand, tumour-specific drug delivery system, increasing the effectiveness of treatment."

基金机构：Basic Scientific Research Project of Chongqing [cstc2019jxjl-jbky10005]

基金资助正文："The authors extend their appreciation to the Basic Scientific Research Project of Chongqing, for funding this research work through project number (cstc2019jxjl-jbky10005)."