Plasticity and crosstalk of mesenchymal stem cells and macrophages in immunomodulation in sepsis

作者全名："Tao, Xingyu; Wang, Jialian; Liu, Bin; Cheng, Peifeng; Mu, Dan; Du, Huimin; Niu, Bailin"

作者地址："[Tao, Xingyu; Wang, Jialian; Liu, Bin; Cheng, Peifeng; Mu, Dan; Niu, Bailin] Chongqing Univ, Sch Med, Dept Crit Care Med, Chongqing Key Lab Emergency Med,Cent Hosp, Chongqing, Peoples R China; [Du, Huimin] Chongqing Med Univ, Affiliated Hosp 1, Dept Oncol, Chongqing, Peoples R China; [Niu, Bailin] Brigham & Womens Hosp, Dept Surg, Boston, MA 02115 USA; [Niu, Bailin] Harvard Med Sch, Boston, MA 02115 USA"

通信作者："Niu, BL (通讯作者)，Chongqing Univ, Sch Med, Dept Crit Care Med, Chongqing Key Lab Emergency Med,Cent Hosp, Chongqing, Peoples R China.; Du, HM (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Oncol, Chongqing, Peoples R China.; Niu, BL (通讯作者)，Brigham & Womens Hosp, Dept Surg, Boston, MA 02115 USA.; Niu, BL (通讯作者)，Harvard Med Sch, Boston, MA 02115 USA."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001159600400001

JCR分区：Q1

影响因子：7.3

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：mesenchymal stem cell; macrophage; immunomodulation; plasticity; crosstalk; sepsis

摘要："Sepsis is a multisystem disease characterized by dysregulation of the host immune response to infection. Immune response kinetics play a crucial role in the pathogenesis and progression of sepsis. Macrophages, which are known for their heterogeneity and plasticity, actively participate in the immune response during sepsis. These cells are influenced by the ever-changing immune microenvironment and exhibit two-sided immune regulation. Recently, the immunomodulatory function of mesenchymal stem cells (MSCs) in sepsis has garnered significant attention. The immune microenvironment can profoundly impact MSCs, prompting them to exhibit dual immunomodulatory functions akin to a double-edged sword. This discovery holds great importance for understanding sepsis progression and devising effective treatment strategies. Importantly, there is a close interrelationship between macrophages and MSCs, characterized by the fact that during sepsis, these two cell types interact and cooperate to regulate inflammatory processes. This review summarizes the plasticity of macrophages and MSCs within the immune microenvironment during sepsis, as well as the intricate crosstalk between them. This remains an important concern for the future use of these cells for immunomodulatory treatments in the clinic."

基金机构："Fundamental Research Funds for the Central Universities [2022CDJYGRH-014]; Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau) [2023ZDXM012, 2021MSXM033]; Medical Research Project of Chongqing Health Commission [2023wsjk082]; Chongqing Science and Technology Bureau Research Project [CSTB2022BSXM-JCX0050]"

基金资助正文："The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Fundamental Research Funds for the Central Universities [2022CDJYGRH-014], Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau) [2023ZDXM012] and [2021MSXM033], Medical Research Project of Chongqing Health Commission [2023wsjk082] and Chongqing Science and Technology Bureau Research Project [CSTB2022BSXM-JCX0050]."