Advances in the study of the correlation between insulin resistance and infertility

作者全名："Lei, Ruobing; Chen, Shuyi; Li, Weihong"

作者地址："[Lei, Ruobing; Chen, Shuyi; Li, Weihong] Chongqing Med Univ, Affiliated Hosp 1, Reprod Med Ctr, Chongqing, Peoples R China"

通信作者："Li, WH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Reprod Med Ctr, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001160211500001

JCR分区：Q2

影响因子：5.2

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：insulin resistance; infertility; assisted reproductive technology; adverse pregnancy outcomes; offspring health

摘要："This is a narrative review of the progress of research on the correlation between insulin resistance and infertility. Insulin resistance (IR) is not only involved in the development of various metabolic diseases, but also affects female reproductive function, and to some extent is closely related to female infertility. IR may increase the risk of female infertility by activating oxidative stress, interfering with energy metabolism, affecting oocyte development, embryo quality and endometrial tolerance, affecting hormone secretion and embryo implantation, as well as affecting assisted conception outcomes in infertile populations and reducing the success rate of assisted reproductive technology treatment in infertile populations. In addition, IR is closely associated with spontaneous abortion, gestational diabetes and other adverse pregnancies, and if not corrected in time, may increase the risk of obesity and metabolic diseases in the offspring in the long term. This article provides a review of the relationship between IR and infertility to provide new ideas for the treatment of infertility."

基金机构：National Natural Science Foundation of China [81501335]; General Program of Chongqing Natural Science Foundation [CSTB2022NSCQ-MSX0086]; Joint Program of the Chongqing Science and Technology Bureau; Chongqing Health Commission [2021MSXM141]

基金资助正文："The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants from the National Natural Science Foundation of China (No. 81501335), the General Program of Chongqing Natural Science Foundation (CSTB2022NSCQ-MSX0086) and the Joint Program of the Chongqing Science and Technology Bureau and the Chongqing Health Commission (No. 2021MSXM141)."