Development and validation of a novel scoring system for acute ischemic stroke

作者全名："Xu, Rui; Peng, Shixin; Qiu, Yulong; Zhu, Ji; Zhang, Xiaodong; Jiang, Li"

作者地址："[Xu, Rui; Peng, Shixin; Qiu, Yulong; Zhu, Ji; Zhang, Xiaodong; Jiang, Li] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Jiang, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF TRANSLATIONAL MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001162661600002

JCR分区：Q1

影响因子：7.4

年份：2024

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Background This study aimed to assess the clinical application of the Artery Occlusion Image Score (AOIS), a new metric based on computed tomographic angiography (CTA) that reflects the severity of occlusive changes in the main intracranial arteries. Materials and Methods Patients diagnosed with acute ischemic stroke (AIS) were divided into three groups: anterior circulation infarcts (ACI group), posterior circulation infarcts (PCI group), and both anterior and posterior circulation infarcts (ACI + PCI group). The sensitivity and specificity of AOIS were evaluated using the Basilar Artery on Computed Tomography Angiography (BATMAN) score, the Clot Burden Score (CBS), and the National Institutes of Health Stroke Scale (NIHSS) as comparators through receiver-operating characteristic (ROC) curve analysis. Results The final analysis included 439 consecutive patients. In the ACI group, AOIS demonstrated high sensitivity (86.3%) and specificity (85.0%) and outperformed CBS in predicting patient prognosis. In the PCI group, AOIS also showed high sensitivity (88.9%) and specificity (90.0%) and outperformed BATMAN in predicting patient prognosis. In the ACI + PCI group, AOIS positively correlated with the NIHSS score (Spearman's rho = 0.602, P < .001). Additionally, the scoring time of AOIS did not significantly differ from CBS and BATMAN. Conclusion AOIS is a convenient and reliable method for guiding treatment and predicting outcomes in patients with ACI or/and PCI. Furthermore, AOIS is the first CTA-based scoring system that covers both the anterior and posterior circulation, providing a convenient and reliable evaluation for patients with concurrent acute ischemic stroke in both circulations."

基金机构：the Future Medical Youth Innovation Team Development Support Plan of Chongqing Medical University (Scientific Research and Innovation Team) [W0169]; Future Medical Youth Innovation Team Development Support Plan of Chongqing Medical University (Scientific Research and Innovation Team) [81701226]; National Natural Science Foundation for Youth of China

基金资助正文："We acknowledge Dr. Jiang for the design and management of this study, Dr. Zhu for the data collection and processing, Dr. Zhang and Dr. Qiu for the data analysis. This work was supported by the Future Medical Youth Innovation Team Development Support Plan of Chongqing Medical University (Scientific Research and Innovation Team, No. W0169) and the National Natural Science Foundation for Youth of China (No. 81701226)."