Causal effects of endometriosis on cancer risk: A Mendelian randomization study

作者全名:"Tang, Tianyou; Yu, Huilin; Xu, Sipei; Zhong, Yi; Ma, Jie; Zhao, Tingting"

作者地址:"[Tang, Tianyou; Zhong, Yi] Chongqing Med Univ, Coll Pediat, Chongqing, Peoples R China; [Yu, Huilin] Chongqing Med Univ, Med Coll 2, Chongqing, Peoples R China; [Xu, Sipei] Chongqing Med Univ, Med Coll 1, Chongqing, Peoples R China; [Ma, Jie] Chongqing Chem Ind Vocat Coll, Pharmaceut Engn Coll, Dept Pharmacol, Chongqing, Peoples R China; [Zhao, Tingting] Chongqing Med Univ, Lab Human Funct Expt Teaching & Management Ctr, Chongqing, Peoples R China"

通信作者:"Zhao, TT (通讯作者),Chongqing Med Univ, Lab Human Funct Expt Teaching & Management Ctr, Chongqing, Peoples R China."












关键词:cancer; endometriosis; Mendelian randomization

摘要:"Endometriosis has been reported in epidemiological studies to be associated with certain types of cancer. However, the presence of reverse causality and residual confounding due to common risk factors introduces uncertainty regarding the extent to which endometriosis itself contributes to the development of cancer. We performed the Mendelian randomization (MR) to investigate the causal associations between endometriosis and 34 different types of cancers. The results of the inverse-variance-weighted (IVW) model suggested that genetic predisposition to endometriosis was causally associated with an increased risk for ovarian cancer (OR = 3.2913; p-value = .0320). The genetic liabilities to endometriosis had causal associations with the decreased risk for skin cancer (OR = 0.9973; p-value = .0219), hematological cancer (OR = 0.9953; p-value = .0175) and ER- breast cancer (OR = 0.6960; p-value = .0381). The causal association of the above combinations were robust by test of heterogeneity and pleiotropy. Together, our study suggests that endometriosis had causal effect on cancer risk."

基金机构:Tutorial System of Excellent Medical Undergraduate

基金资助正文:"2023 Science and Technology Plan Projects of Changshou District, Grant/Award Number:CSKJ025; National Innovation and Entrepreneurship Training Program, Grant/Award Number: SRIEP202104; Tutorial System of Excellent Medical Undergraduate, Grant/Award Number: LTMCMTS202212r No Statement Availabler No Statement Available"