"Personality traits predict treatment outcome of an antidepressant in untreated adolescents with depression: An 8-week, open-label, flexible-dose study"

作者全名："Ran, Liu-Yi; Liu, Xin-Yi; Wang, Wo; Tao, Wan-Qing; Xiang, Jiao-Jiao; Zeng, Qi; Kong, Yi-Ting; Zhang, Chen -Yu; Liao, Jing; Qiu, Hai -Tang; Kuang, Li"

作者地址："[Ran, Liu-Yi; Liu, Xin-Yi; Wang, Wo; Tao, Wan-Qing; Zeng, Qi; Liao, Jing] Chongqing Med Univ, Mental Hlth Ctr, Town Hosp, 55,Univ Town Middle Rd, Chongqing 401331, Peoples R China; [Xiang, Jiao-Jiao; Kong, Yi-Ting; Zhang, Chen -Yu; Qiu, Hai -Tang; Kuang, Li] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Ran, Liu-Yi; Wang, Wo; Qiu, Hai -Tang; Kuang, Li] Chongqing Clin Med Res Ctr Psychiat & Psychol Diso, Chongqing, Peoples R China"

通信作者："Qiu, HT; Kuang, L (通讯作者)，Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：JOURNAL OF AFFECTIVE DISORDERS

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001168653600001

JCR分区：Q1

影响因子：6.6

年份：2024

卷号：350

期号：　

开始页：102

结束页：109

文献类型：Article

关键词：Personality traits; Adolescent depression; Predict treatment response; SSRI

摘要："Background: Antidepressant response in adults with major depressive disorder (MDD) is probably influenced by personality dimensions. However, personality dimensions in depression and their association with antidepressant treatment in adolescents are relatively unknown. We sought to investigate whether personality traits (PTs) can influence antidepressant treatment response in adolescents with depression. Methods: Eighty-two adolescents with MDD who had completed the 8 weeks of treatment with selective serotonin reuptake inhibitors (SSRI) were enrolled. The Revised NEO Five-Factor Inventory (NEO-FFI-R) was used to measure their personality at baseline, and the 17-item Hamilton Depression Rating Scale (HAMD-17) and Children's Depression Rating Scale-Revised (CDRS-R) were used to evaluate depressive symptoms at baseline and 8 weeks. Moreover, logistic regression was performed to investigate the relationship between personality dimensions and antidepressant response. Receiver operating characteristic analyses were employed to determine the accuracy of a PT-based model in predicting the antidepressant response rate. Results: Adolescents with MDD had significantly different PTs at baseline. Multivariable logistic regression analysis showed that extroversion scores were associated with response to antidepressant treatment, the lower the extroversion score, the better the response to antidepressant treatment, after correcting for variables with significant differences and trends or all potential confounding variables. It was also found that the combination of disease duration, extraversion-gregariousness, and agreeableness-trust effectively predicted antidepressant response in adolescents with MDD, with a sensitivity of 79.4 % and specificity of 68.7 %. Conclusion: Personality dysfunction in adolescents is associated with MDD. The antidepressant treatment response is influenced by the degree of extroversion in adolescents with MDD."

基金机构："National Natural Science Foundation of China [82101615, 81971286, 81901373]; Natural Science Foundation of Chongqing, China [cstc2021jcyj-msxmX0349]; Science and Health Joint Medical Research Project Fund of Chongqing [2022QNXM001]"

基金资助正文："Role of the funding source This study was funded by the National Natural Science Foundation of China (Grant NO. 82101615) , (Grant NO. 81971286) , (Grant NO. 81901373) and the Natural Science Foundation of Chongqing, China (Grant NO. cstc2021jcyj-msxmX0349) , and the Science and Health Joint Medical Research Project Fund of Chongqing (Grant NO. 2022QNXM001) ."