Estimated Pulse Wave Velocity Predicts All-Cause and Cardiovascular-Cause Mortality in Individuals With Hypertension ― Findings From a National Health and Nutrition Examination Study 1999-2018

作者全名："Shi, Yi; Wu, Li -Da; Feng, Xiao-Hua; Kan, Jun-Yan; Kong, Chao-Hua; Ling, Zhi-Yu; Zhang, Jun-Xia; Chen, Shao-Liang"

作者地址："[Shi, Yi; Wu, Li -Da; Kan, Jun-Yan; Kong, Chao-Hua; Zhang, Jun-Xia; Chen, Shao-Liang] Nanjing Med Univ, Nanjing Hosp 1, Dept Cardiol, 68 Changle Rd, Nanjing 210006, Peoples R China; [Feng, Xiao-Hua] Nanjing Med Univ, Dept Geriatr, Affiliated Hosp 1, Nanjing, Peoples R China; [Ling, Zhi-Yu] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing 400000, Peoples R China"

通信作者："Zhang, JX; Chen, SL (通讯作者)，Nanjing Med Univ, Nanjing Hosp 1, Dept Cardiol, 68 Changle Rd, Nanjing 210006, Peoples R China.; Ling, ZY (通讯作者)，Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing 400000, Peoples R China."

来源：CIRCULATION JOURNAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001171496300015

JCR分区：Q2

影响因子：3.3

年份：2024

卷号：88

期号：3

开始页：　

结束页：　

文献类型：Article

关键词：All-cause mortality; Arterial stiffness; Estimated pulse wave velocity (ePWV); Hypertension; National Health and Nutrition Examination Survey (NHANES)

摘要："Background: This study aimed to investigate the association between estimated pulse wave velocity (ePWV) and mortality outcomes among individuals with hypertension. Methods and Results: Based on the National Health and Nutrition Examination Survey (NHANES) 1999-2018, a total of 14,396 eligible participants with hypertension were enrolled. The ePWV was calculated using the equation based on blood pressure and age. The mortality outcomes of included participants were directly acquired from the National Death Index database. The multivariable Cox regression analysis was used to examine the relationship between ePWV and mortality outcomes. Moreover, the restricted cubic spline (RCS) was also used to explore this relationship. Receiver operating characteristics curves (ROC) were adopted to evaluate the prognostic ability of ePWV for predicting mortality outcomes of patients with hypertension. The median follow-up duration was 10.8 years; individuals with higher an ePWV had higher risks of mortality from both all causes (HR: 2.79, 95% CI: 2.43-3.20) and cardiovascular diseases (HR: 3.41, 95% CI: 2.50-4.64). After adjusting for confounding factors, each 1 m/s increase in ePWV was associated with a 43% increase in all -cause mortality risk (HR: 1.43, 95% CI: 1.37-1.48) and a 54% increase in cardiovascular mortality risk (HR: 1.54, 95% CI: 1.43-1.66). Conclusions: This study indicates that ePWV is a novel prognostic indicator for predicting the risks of mortality among patients with hypertension."

基金机构："National Natural Science Foundation of China [81970309, 82170350]"

基金资助正文：Sources of Funding This research is funded by the National Natural Science Foundation of China (Grant No. 81970309 and No. 82170350) .