Overexpression of Aurora Kinase B Is Correlated with Diagnosis and Poor Prognosis in Hepatocellular Carcinoma

作者全名："Zhang, Jin; Ma, Jiaxiu; Li, Yalan; An, Yaxin; Du, Wei; Yang, Qun; Huang, Meiling; Cai, Xuefei"

作者地址："[Zhang, Jin; Ma, Jiaxiu; Li, Yalan; An, Yaxin; Du, Wei; Yang, Qun; Huang, Meiling; Cai, Xuefei] Chongqing Med Univ, Chinese Minist Educ, Key Lab Mol Biol Infect Dis, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Cai, XF (通讯作者)，Chongqing Med Univ, Chinese Minist Educ, Key Lab Mol Biol Infect Dis, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ESI学科分类：CHEMISTRY

WOS号：WOS:001172057300001

JCR分区：Q2

影响因子：5.6

年份：2024

卷号：25

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：aurora kinase B (AURKB); hepatocellular carcinoma (HCC); cell cycle; diagnosis; prognosis

摘要："Aurora kinase B (AURKB) overexpression promotes tumor initiation and development by participating in the cell cycle. In this study, we focused on the mechanism of AURKB in hepatocellular carcinoma (HCC) progression and on AURKB's value as a diagnostic and prognostic biomarker in HCC. We used data from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) to analyze AURKB expression in HCC. We found that the expression levels of AURKB in HCC samples were higher than those in the corresponding control group. R packages were used to analyze RNA sequencing data to identify AURKB-related differentially expressed genes (DEGs), and these genes were found to be significantly enriched during the cell cycle. The biological function of AURKB was verified, and the results showed that cell proliferation was slowed down and cells were arrested in the G2/M phase when AURKB was knocked down. AURKB overexpression resulted in significant differences in clinical symptoms, such as the clinical T stage and pathological stage. Kaplan-Meier survival analysis, Cox regression analysis, and Receiver Operating Characteristic (ROC) curve analysis suggested that AURKB overexpression has good diagnostic and prognostic potential in HCC. Therefore, AURKB may be used as a potential target for the diagnosis and cure of HCC."

基金机构：National Key R&D Program of China

基金资助正文：No Statement Available