Classifying hepatitis B therapies with insights from covalently closed circular DNA dynamics

作者全名："Hu, Jie-Li; Huang, Ai-Long"

作者地址："[Hu, Jie-Li; Huang, Ai-Long] Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Minist Educ, Chongqing 400016, Peoples R China"

通信作者："Hu, JL; Huang, AL (通讯作者)，Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Minist Educ, Chongqing 400016, Peoples R China."

来源：VIROLOGICA SINICA

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001172879600001

JCR分区：Q3

影响因子：5.5

年份：2024

卷号：39

期号：1

开始页：9

结束页：23

文献类型：Review

关键词：Hepatitis B; cccDNA; Functional cure; Dynamics; Treatment; Strategy

摘要："The achievement of a functional cure for chronic hepatitis B (CHB) remains limited to a minority of patients treated with currently approved drugs. The primary objective in developing new anti-HBV drugs is to enhance the functional cure rates for CHB. A critical prerequisite for the functional cure of CHB is a substantial reduction, or even eradication of covalently closed circular DNA (cccDNA). Within this context, the changes in cccDNA levels during treatment become as a pivotal concern. We have previously analyzed the factors influencing cccDNA dynamics and introduced a preliminary classification of hepatitis B treatment strategies based on these dynamics. In this review, we employ a systems thinking perspective to elucidate the fundamental aspects of the HBV replication cycle and to rationalize the classification of treatment strategies according to their impact on the dynamic equilibrium of cccDNA. Building upon this foundation, we categorize current anti-HBV strategies into two distinct groups and advocate for their combined use to significantly reduce cccDNA levels within a welldefined timeframe."

基金机构："National Key R&D Program of China [2022YFA1303600]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0298]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJZD-K202200409]; The 111 Project [D20028]; Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University [202104]; CQMU Program for Youth Innovation in Future Medicine [W0049]"

基金资助正文："This work was supported by grants from the National Key R&D Program of China (2022YFA1303600) , the Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0298) , the Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No. KJZD-K202200409) , the 111 Project (No. D20028) , Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University (No. 202104) , and CQMU Program for Youth Innovation in Future Medicine (No. W0049) ."