Facile synthesis of nitrogen-doped carbon dots for ultrasensitive detection of anticancer drug gefitinib based on IFE

作者全名："He, Yuxin; Wang, Hanting; Yan, Yuting; Jiang, Xinhui; Zou, Hecun; Zhang, Zhengwei"

作者地址："[He, Yuxin; Yan, Yuting; Jiang, Xinhui; Zou, Hecun; Zhang, Zhengwei] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Wang, Hanting] Chongqing Med Univ, Sch Basic Med Sci, Dept Forens Med, Chongqing 400016, Peoples R China; [Zou, Hecun] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China"

通信作者："Zou, HC; Zhang, ZW (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China.; Zou, HC (通讯作者)，Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China."

来源：SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

ESI学科分类：CHEMISTRY

WOS号：WOS:001173151300001

JCR分区：Q1

影响因子：4.4

年份：2024

卷号：310

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Nitrogen-doped carbon dots; Gefitinib; Fluorescence sensing; Inner filter effect

摘要："Gefitinib, a highly significant antitumor drug, is now commonly employed in clinical settings as a first -line treatment for patients with advanced or metastatic non -small cell lung cancer, colon cancer, and breast cancer. Herein, a convenient, rapid, and accurate fluorescence method based on nitrogen-doped carbon dots (NCDs) was designed for ultrasensitive detection of gefitinib. The NCDs were easily synthesized through one -pot hydrothermal process using p-phenylenediamine and D-glutamic acid as the precursors. The sensing strategy relied on the fluorescence of NCDs at 345 nm, which was selectively reduced by gefitinib based on the inner filter effect (IFE). With a broad linear range of 0.025-30 mu g/mL and a low limit of detection of 5.5 ng/mL, the probe was successfully applied to the detection of gefitinib in human serum samples, demonstrating strong practicality, affordability, and high accuracy. The proposed sensor is simple in design, fast in detection and cost-effective, and exhibits promising application in drug real -time analysis."

基金机构："National Natural Science Foundation of China [82003713, 82003854]; Natural Science Foundation of Chongqing [cstc2020jcyj-msxmX0158, cstc2021jcyj-msxmX0302]; CQMU Program for Youth Innovation in Future Medicine [W0152]"

基金资助正文："This work was funded by the National Natural Science Foundation of China (82003713 and 82003854) , the Natural Science Foundation of Chongqing (cstc2020jcyj-msxmX0158 and cstc2021jcyj-msxmX0302) , and CQMU Program for Youth Innovation in Future Medicine (W0152) ."