The causal effect of air pollution on the risk of essential hypertension: a Mendelian randomization study

作者全名："Xia, Zhiwei; Liu, Yinjiang; Liu, Chao; Dai, Ziyu; Liang, Xisong; Zhang, Nan; Wu, Wantao; Wen, Jie; Zhang, Hao"

作者地址："[Xia, Zhiwei] Hunan Aerosp Hosp, Dept Neurol, Changsha, Hunan, Peoples R China; [Liu, Yinjiang; Zhang, Hao] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing, Peoples R China; [Liu, Chao] Cent Hosp Zhuzhou, Dept Neurosurg, Zhuzhou 412000, Hunan, Peoples R China; [Dai, Ziyu; Liang, Xisong; Wen, Jie] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Hunan, Peoples R China; [Dai, Ziyu; Liang, Xisong; Wen, Jie] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China; [Zhang, Nan] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan, Hubei, Peoples R China; [Wu, Wantao] Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha, Hunan, Peoples R China"

通信作者："Zhang, H (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing, Peoples R China.; Wen, J (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Hunan, Peoples R China.; Wen, J (通讯作者)，Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China."

来源：FRONTIERS IN PUBLIC HEALTH

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:001173950400001

JCR分区：Q1

影响因子：5.2

年份：2024

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：PM2.5; PM10; hypertension; Mendelian randomization (MR); air pollution

摘要："Background Air pollution poses a major threat to human health by causing various illnesses, such as cardiovascular diseases. While plenty of research indicates a correlation between air pollution and hypertension, a definitive answer has yet to be found.Methods Our analyses were performed using the Genome-wide association study (GWAS) of exposure to air pollutants from UKB (PM2.5, PM10, NO2, and NOX; n = 423,796 to 456,380), essential hypertension from FinnGen (42,857 cases and 162,837 controls) and from UKB (54,358 cases and 408,652 controls) as a validated cohort. Univariable and multivariable Mendelian randomization (MR) were conducted to investigate the causal relationship between air pollutants and essential hypertension. Body mass index (BMI), alcohol intake frequency, and the number of cigarettes previously smoked daily were included in multivariable MRs (MVMRs) as potential mediators/confounders.Results Our findings suggested that higher levels of both PM2.5 (OR [95%CI] per 1 SD increase in predicted exposure = 1.24 [1.02-1.53], p = 3.46E-02 from Finn; OR [95%CI] = 1.04 [1.02-1.06], p = 7.58E-05 from UKB) and PM10 (OR [95%CI] = 1.24 [1.02-1.53], p = 3.46E-02 from Finn; OR [95%CI] = 1.04 [1.02-1.06], p = 7.58E-05 from UKB) were linked to an increased risk for essential hypertension. Even though we used MVMR to adjust for the impacts of smoking and drinking on the relationship between PM2.5 exposure and essential hypertension risks, our findings suggested that although there was a direct positive connection between them, it is not present after adjusting BMI (OR [95%CI] = 1.05 [0.87-1.27], p = 6.17E-01). Based on the study, higher exposure to PM2.5 and PM10 increases the chances of developing essential hypertension, and this influence could occur through mediation by BMI.Conclusion Exposure to both PM2.5 and PM10 is thought to have a causal relationship with essential hypertension. Those impacted by substantial levels of air pollution require more significant consideration for their cardiovascular health."

基金机构：High Performance Computing Center of Central South University

基金资助正文："The authors appreciate the public databases, Biorender online tool (Biorender.com), websites, and software used in the study, as well as their contributors, and thank the High Performance Computing Center of Central South University for the support of this work."