Association of systemic inflammatory response index and plaque characteristics with the severity and recurrence of cerebral ischemic events

作者全名："Wei, Xiaofan; Cheng, Jie; Zhang, Limin; Xu, Ruoyu; Zhang, Wei"

作者地址："[Wei, Xiaofan; Zhang, Limin; Xu, Ruoyu; Zhang, Wei] Chongqing Med Univ, Affiliated Hosp 2, Dept Radiol, Chongqing 400010, Peoples R China; [Cheng, Jie] Army Med Univ, Third Mil Med Univ, Southwest Hosp, Dept Radiol, Chongqing 400038, Peoples R China"

通信作者："Zhang, W (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Radiol, Chongqing 400010, Peoples R China."

来源：JOURNAL OF STROKE & CEREBROVASCULAR DISEASES

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001174681400001

JCR分区：Q2

影响因子：2.5

年份：2024

卷号：33

期号：3

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结束页：　

文献类型：Article

关键词：Intracranial atherosclerotic disease; Ischemic stroke; High-resolution magnetic resonance vessel wall; imaging; Systemic inflammatory response index

摘要："Aim: We aimed to investigate the relationship between systemic inflammatory response index (SIRI) and intracranial plaque features, as well as the risk factors related to the severity and recurrence of cerebral ischemic events. Methods: We enrolled 170 patients with cerebral ischemic events. Baseline demographic characteristics and laboratory indicators were collected from all participants. All patients were assessed by high-resolution magnetic resonance vessel wall imaging for culprit plaque characteristics and intracranial atherosclerotic burden. Outpatient or telephone follow-up were conducted at 1, 3, and 6 months after discharge. Results: SIRI levels were significantly associated with the enhanced plaque number (r = 0.205, p = 0.007), total plaque stenosis score (r = 0.178, p = 0.020), total plaque enhancement score (r = 0.222, p = 0.004), intraplaque hemorrhage (F = 5.630, p = 0.004), and plaque surface irregularity (F = 3.986, p = 0.021). Higher SIRI levels (OR = 1.892), total plaque enhancement score (OR = 1.392), intraplaque hemorrhage (OR = 3.370) and plaque surface irregularity (OR = 2.846) were independent risk factors for moderate-severe stroke, and these variables were significantly positively correlated with NIHSS (P < 0.05 for all). In addition, higher age (HR = 1.063, P = 0.015), higher SIRI levels (HR = 2.003, P < 0.001), and intraplaque hemorrhage (HR = 4.482, P = 0.008) were independently associated with recurrent stroke. Conclusions: Higher SIRI levels may have adverse effects on the vulnerability and burden of intracranial plaques, and links to the severity and recurrence of ischemic events. Therefore, SIRI may provide important supplementary information for evaluating intracranial plaque stability and risk stratification of patients."

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