"Emerging roles of circular RNAs in tumorigenesis, progression, and treatment of gastric cancer"

作者全名："Ma, Qiang; Yang, Feifei; Xiao, Bin; Guo, Xiaolan"

作者地址："[Ma, Qiang; Guo, Xiaolan] North Sichuan Med Coll, Dept Clin Lab, Affiliated Hosp, Nanchong 637000, Peoples R China; [Ma, Qiang; Guo, Xiaolan] North Sichuan Med Coll, Translat Med Res Ctr, Nanchong 637000, Peoples R China; [Ma, Qiang; Guo, Xiaolan] North Sichuan Med Coll, Sch Lab Med, Nanchong 637000, Peoples R China; [Yang, Feifei; Xiao, Bin] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China"

通信作者："Guo, XL (通讯作者)，North Sichuan Med Coll, Dept Clin Lab, Affiliated Hosp, Nanchong 637000, Peoples R China.; Guo, XL (通讯作者)，North Sichuan Med Coll, Translat Med Res Ctr, Nanchong 637000, Peoples R China.; Guo, XL (通讯作者)，North Sichuan Med Coll, Sch Lab Med, Nanchong 637000, Peoples R China.; Xiao, B (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China."

来源：JOURNAL OF TRANSLATIONAL MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001175646000003

JCR分区：Q1

影响因子：7.4

年份：2024

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：circRNA; Gastric cancer; miRNA sponge; RNA binding protein; Translational template; Biotechnological drugs

摘要："With an estimated one million new cases reported annually, gastric cancer (GC) ranks as the fifth most diagnosed malignancy worldwide. The early detection of GC remains a major challenge, and the prognosis worsens either when patients develop resistance to chemotherapy or radiotherapy or when the cancer metastasizes. The precise pathogenesis underlying GC is not well understood, which further complicates its treatment. Circular RNAs (circRNAs), a recently discovered class of noncoding RNAs that originate from parental genes through ""back-splicing"", have been shown to play a key role in various biological processes in both eukaryotes and prokaryotes. CircRNAs have been linked to cardiovascular diseases, diabetes, hypertension, Alzheimer's disease, and the occurrence and progression of tumors. Prior studies have established that circRNAs play a crucial role in GC, impacting tumorigenesis, diagnosis, progression, and therapy resistance. This review aims to summarize how circRNAs contribute to GC tumorigenesis and progression, examine their roles in the development of drug resistance, discuss their potential as biotechnological drugs, and summarize their response to therapeutic drugs and microorganism in GC."

基金机构：Science and Technology Support Program of Nanchong [22SXQT0001]; Youth medical innovation research project of Sichuan province [Q23047]; Scientific research foundation for advanced talents; Affiliated hospital of North Sichuan Medical College [2023GC009]

基金资助正文："This research was funded by the Science and Technology Support Program of Nanchong (Grant No. 22SXQT0001), Scientific research foundation for advanced talents, Affiliated hospital of North Sichuan Medical College (2023GC009), and Youth medical innovation research project of Sichuan province (Q23047)."