Immunohistochemical markers Ki67 and P16 help predict prognosis in locally advanced cervical cancer

作者全名："Wu, Jialin; Wang, Rong; Chen, Wanli; Wu, Yingyu; Xiao, Lin"

作者地址："[Wu, Jialin; Wang, Rong; Chen, Wanli; Wu, Yingyu; Xiao, Lin] Chongqing Med Univ, Affiliated Hosp 1, Dept Gynaecol, Chongqing, Peoples R China; [Xiao, Lin] Chongqing Med Univ, Affiliated Hosp 1, Dept Gynaecol, Chongqing 400016, Peoples R China"

通信作者："Xiao, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Gynaecol, Chongqing 400016, Peoples R China."

来源：EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001177338900001

JCR分区：Q3

影响因子：2.6

年份：2024

卷号：294

期号：　

开始页：210

结束页：216

文献类型：Article

关键词：Cervical cancer; Neoadjuvant chemotherapy; Ki-67; P16; Recurrence -free survival

摘要："Objective: To investigate the relationship between Ki-67 and P16 expression levels after neoadjuvant chemotherapy, and the clinicopathological characteristics and prognosis of patients with locally advanced cervical cancer. Methods: Patients with FIGO 2009 stage IB2 or IIA2 cervical cancer, who underwent neoadjuvant chemotherapy combined with radical hysterectomy at the First Affiliated Hospital of Chongqing Medical University between January 2015 and December 2019, were identified retrospectively to correlate postoperative Ki-67 and P16 expression levels with clinicopathological factors. The optimal threshold for predicting recurrence was analysed using receiver operating characteristic (ROC) curves for the Ki-67 index, and univariate and multi -factorial Cox regression analysis were used to investigate the association between clinicpathological features including Ki-67 and P16 and recurrence -free survival. Results: In total, 334 patients were included after screening. The cut-off value of Ki-67 for determining recurrence was 67.5 % according to the ROC curve. On multi -factorial Cox analysis, lymphatic vascular space (p = 0.003) and Ki-67 index (p = 0.005) were shown to increase the risk of recurrence, and were independent prognostic factors for recurrence, while the expression of P16 was not significantly associated with the risk of recurrence (p = 0.097, odds ratio = 0.319). Patients with cervical cancer in the high Ki-67 expression group (Ki-67 >= 67.5 %) had lower recurrence -free survival and overall survival than patients in the low Ki-67 expression group (Ki-67 < 67.5 %) (p = 0.001 and 0.036, respectively). Conclusion: The expression levels of Ki-67 and P16 after neoadjuvant chemotherapy for locally advanced cervical cancer correlated with tumour differentiation. High expression of Ki-67 (Ki-67 >= 67.5 %) may indicate poorer recurrence -free survival and overall survival."

基金机构："Natural Science Foundation of Chongqing, China [cstc2021jcyj-msxmX0120]"

基金资助正文："<BOLD>Funding</BOLD> This work was supported by the Natural Science Foundation of Chongqing, China (No cstc2021jcyj-msxmX0120) ."