Deciphering chemoresistance in osteosarcoma: Unveiling regulatory mechanisms and function through the lens of noncoding RNA

作者全名："Chen, Hefen; Gong, Zhujun; Zhou, Hong; Han, Yong"

作者地址："[Chen, Hefen; Gong, Zhujun; Zhou, Hong; Han, Yong] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pharm, Wuhan, Peoples R China; [Gong, Zhujun] Chongqing Med Univ, Dept Pharm, Chongqing, Peoples R China; [Zhou, Hong; Han, Yong] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430022, Peoples R China"

通信作者："Zhou, H; Han, Y (通讯作者)，Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430022, Peoples R China."

来源：DRUG DEVELOPMENT RESEARCH

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001178851900001

JCR分区：Q1

影响因子：3.8

年份：2024

卷号：85

期号：2

开始页：　

结束页：　

文献类型：Review

关键词：chemoresistance; noncoding RNA; osteosarcoma

摘要："Osteosarcoma (OS) is a primary malignant bone tumor and is prevalent in children, adolescents, and elderly individuals. It has the characteristics of high invasion and metastasis. Neoadjuvant chemotherapy combined with surgical resection is the most commonly used treatment for OS. However, the efficacy of OS is considerably diminished by chemotherapy resistance. In recent years, noncoding RNAs (ncRNAs), including microRNAs, long noncoding RNAs, and circular RNAs, are hot topics in the field of chemotherapy resistance research. Several studies have demonstrated that ncRNAs are substantially associated with chemoresistance in OS. Thus, the present study overviews the abnormally expressed ncRNAs in OS and the molecular mechanisms involved in chemoresistance, with an emphasis on their function in promoting or inhibiting chemoresistance. ncRNAs are expected to become potential therapeutic targets for overcoming drug resistance and predictive biomarkers in OS, which are of great significance for enhancing the therapeutic effect and improving the prognosis."

基金机构：National Natural Science Foundation of China; [81673456]

基金资助正文：This work was supported by grants from the National Natural Science Foundation of China (Grant No. 81673456).