A multi-tissue metabolome atlas of primate pregnancy
作者全名："Yu, Dainan; Wan, Haifeng; Tong, Chao; Guang, Lu; Chen, Gang; Su, Jiali; Zhang, Lan; Wang, Yue; Xiao, Zhenyu; Zhai, Jinglei; Yan, Long; Ma, Wenwu; Liang, Kun; Liu, Taoyan; Wang, Yuefan; Peng, Zehang; Luo, Lanfang; Yu, Ruoxuan; Li, Wei; Qi, Hongbo; Wang, Hongmei; Shyh-Chang, Ng"
作者地址："[Yu, Dainan; Wan, Haifeng; Guang, Lu; Chen, Gang; Su, Jiali; Wang, Yue; Xiao, Zhenyu; Zhai, Jinglei; Yan, Long; Ma, Wenwu; Liang, Kun; Liu, Taoyan; Wang, Yuefan; Peng, Zehang; Luo, Lanfang; Yu, Ruoxuan; Li, Wei; Wang, Hongmei; Shyh-Chang, Ng] Chinese Acad Sci, Inst Zool, Key Lab Organ Regenerat & Reconstruct, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China; [Qi, Hongbo] Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Chongqing 401120, Peoples R China; [Yu, Dainan; Wan, Haifeng; Guang, Lu; Chen, Gang; Su, Jiali; Wang, Yue; Xiao, Zhenyu; Zhai, Jinglei; Yan, Long; Ma, Wenwu; Liang, Kun; Liu, Taoyan; Wang, Yuefan; Peng, Zehang; Luo, Lanfang; Yu, Ruoxuan; Li, Wei; Wang, Hongmei; Shyh-Chang, Ng] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China; [Yu, Dainan; Wan, Haifeng; Guang, Lu; Chen, Gang; Su, Jiali; Wang, Yue; Xiao, Zhenyu; Zhai, Jinglei; Yan, Long; Ma, Wenwu; Liang, Kun; Liu, Taoyan; Wang, Yuefan; Peng, Zehang; Luo, Lanfang; Yu, Ruoxuan; Li, Wei; Wang, Hongmei; Shyh-Chang, Ng] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Yu, Dainan; Wan, Haifeng; Guang, Lu; Chen, Gang; Su, Jiali; Wang, Yue; Xiao, Zhenyu; Zhai, Jinglei; Yan, Long; Ma, Wenwu; Liang, Kun; Liu, Taoyan; Wang, Yuefan; Peng, Zehang; Luo, Lanfang; Yu, Ruoxuan; Li, Wei; Wang, Hongmei; Shyh-Chang, Ng] Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China; [Tong, Chao; Zhang, Lan] Chongqing Med Univ, State Key Lab Maternal & Fetal Med Chongqing Munic, Chongqing 400016, Peoples R China"
通信作者："Li, W; Wang, HM; Shyh-Chang, N (通讯作者)，Chinese Acad Sci, Inst Zool, Key Lab Organ Regenerat & Reconstruct, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China.; Qi, HB (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Chongqing 401120, Peoples R China.; Li, W; Wang, HM; Shyh-Chang, N (通讯作者)，Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China.; Li, W; Wang, HM; Shyh-Chang, N (通讯作者)，Univ Chinese Acad Sci, Beijing 100049, Peoples R China.; Li, W; Wang, HM; Shyh-Chang, N (通讯作者)，Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China."
来源：CELL
ESI学科分类：MOLECULAR BIOLOGY & GENETICS
WOS号：WOS:001179311200001
JCR分区：Q1
影响因子：64.5
年份：2024
卷号：187
期号：3
开始页：
结束页：
文献类型：Article
关键词：
摘要："Pregnancy induces dramatic metabolic changes in females; yet, the intricacies of this metabolic reprogramming remain poorly understood, especially in primates. Using cynomolgus monkeys, we constructed a comprehensive multi -tissue metabolome atlas, analyzing 273 samples from 23 maternal tissues during pregnancy. We discovered a decline in metabolic coupling between tissues as pregnancy progressed. Core metabolic pathways that were rewired during primate pregnancy included steroidogenesis, fatty acid metabolism, and arachidonic acid metabolism. Our atlas revealed 91 pregnancy -adaptive metabolites changing consistently across 23 tissues, whose roles we verified in human cell models and patient samples. Corticosterone and palmitoyl-carnitine regulated placental maturation and maternal tissue progenitors, respectively, with implications for maternal preeclampsia, diabetes, cardiac hypertrophy, and muscle and liver regeneration. Moreover, we found that corticosterone deficiency induced preeclampsia-like inflammation, indicating the atlas's potential clinical value. Overall, our multi -tissue metabolome atlas serves as a framework for elucidating the role of metabolic regulation in female health during pregnancy."
基金机构："National Key R&D Program of China, China [2019YFA0801701, 2021YFC2700302]; National Natural Science Foundation of China, China [91957202]; CAS Project for Young Scientists in Basic Research [YSBR-012]; Strategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine; Howard Hughes Medical Institute (HHMI) International Research Scholar"
基金资助正文："This work was supported by the National Key R & D Program of China, China (2019YFA0801701 and 2021YFC2700302) , the National Natural Science Foundation of China, China (91957202) , the CAS Project for Young Scientists in Basic Research (YSBR-012) , and the Strategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine. N.S.-C. is also a Howard Hughes Medical Institute (HHMI) International Research Scholar."
