Postoperative esketamine improves ventilation after video-assisted thoracoscopic lung resection: A double-blinded randomized controlled trial

作者全名:"Fu, Mengyue; Xu, Rui; Chen, Guizhen; Zheng, Xuemei; Shu, Bin; Huang, He; Duan, Guangyou; Chen, Yuanjing"

作者地址:"[Fu, Mengyue; Xu, Rui; Chen, Guizhen; Zheng, Xuemei; Shu, Bin; Huang, He; Duan, Guangyou; Chen, Yuanjing] Chongqing Med Univ, Affiliated Hosp 2, Dept Anaesthesiol, Chongqing, Peoples R China; [Huang, He; Duan, Guangyou; Chen, Yuanjing] 74 Lin Jiang Rd, Chongqing 400010, Peoples R China"

通信作者:"Duan, GY; Chen, YJ (通讯作者),Chongqing Med Univ, Affiliated Hosp 2, Dept Anaesthesiol, Chongqing, Peoples R China.; Duan, GY; Chen, YJ (通讯作者),74 Lin Jiang Rd, Chongqing 400010, Peoples R China."

来源:HELIYON

ESI学科分类: 

WOS号:WOS:001180045800001

JCR分区:Q1

影响因子:3.4

年份:2024

卷号:10

期号:3

开始页: 

结束页: 

文献类型:Article

关键词:Video-assisted thoracoscopy; postoperative pulmonary function; Postoperative pulmonary complication; Esketamine; Randomized controlled trial

摘要:"Background: Pain management after lung resection plays a crucial role in reducing postoperative pulmonary complications (PPCs). This study aimed to examine the effect of postoperative esketamine infusion as an adjunct to opioid analgesia on ventilation and pulmonary complications in patients underwent lung resection. Methods: Patients undergoing video-assisted thoracoscopic lung resection were randomly assigned to either the esketamine group or the control group. The esketamine group received a 24-h infusion of 1.5 mcg/ml sufentanil combined with 0.75 mcg/ml esketamine after surgery, while the control group received 1.5 mcg/ml sufentanil alone. The primary outcome measure was low minute ventilation, and the secondary outcome measures were hypoxemia, PaO2/FiO2 levels, postoperative pulmonary complications, hospital stay duration, ambulation time, Visual Analogue Scale (VAS) score, depression and anxiety levels, sleep quality, and analgesia satisfaction. Results: 80 patients were randomly divided into two groups: the esketamine group (n = 40) and the control group (n = 40). The esketamine group exhibited notably reduced incidence of low minute ventilation (P = 0.014), lower occurrence of postoperative pulmonary complications (PPCs) compared to the control group (P = 0.039), and decreased incidence of hypoxemia (P = 0.003). Furthermore, the esketamine group showed improved outcomes with lower VAS scores on the second postoperative day and enhanced sleep quality (P < 0.001) after the surgery. Conclusions: Postoperative esketamine infusion with opioids improved ventilation and reduced PPCs after lung resection, warranting further clinical studies."

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